多孔β-0TCP/BMP复合人工骨引导牙周组织再生的实验研究  

Periodontal regeneration by application of the porous β-TCP/BMP artificial bone to class II furcation defects

作　　者：贾晓真[1] 樊明文[1] 任铁冠 李成章[1] 

机构地区：[1]湖北医科大学口腔医学院牙周科,武汉430079

出　　处：《中华口腔医学杂志》2000年第3期200-202,I018,共3页Chinese Journal of Stomatology

摘　　要：目的　将骨形成蛋白 (bonemorphogeneticprotein ,BMP)和多孔 β磷酸三钙 (β tricalciumphosphate ,β TCP)复合人工骨联合应用于引导组织再生 (guidedtissueregeneration ,GTR)技术中 ,评价其对Ⅱ度根分叉病变牙周组织再生修复的影响和意义。方法　用健康成年杂种狗 4只 ,制备下颌后牙区人工骨缺损。实验牙位随机分为 3组 :①骨形成蛋白 /引导组织再生 (BMP/GTR)组 :缺损处植入引导膜材料和复合人工骨 ;②GTR组 :单纯放置引导膜材料 ;③以常规翻瓣术为对照组。术后 12周取材做组织学观察和评价。结果　两实验组均有明显新附着形成 ,其中BMP/GTR组有大量新生牙槽骨、牙骨质、牙周韧带生长。对照组新生组织量很少。结论　β TCP/BMP是一种具有较强骨诱导能力 ,生物相容性较好的复合人工骨 。Objective To study the regeneration of periodontal tissue after the application of β TCP/BMP artificial bone to class Ⅱ furcation defects. Methods Periodontal defects were produced surgically around premolar teeth in 4 dogs. The flap surgery was performed and the root surfaces were curetted to remove the periodontal ligament and the cementum. A synthetic bioabsorble barrier manufactured from poly DL lactide was used. The defects were divided into 3 groups (β TCP/BMP+PDLLA、PDLLA、 control). 12 weeks after surgery, the animals were sacrificed and the teeth with their supporting periodontium were processed for light microscopic evaluation. Results The definitive evidences of regeneration were founded both in BMP/GTR group and GTR group, but the BMP/GTR group exhibited more new bone formation, cementum deposition occupying the majority of the furcation defects than the other two groups. Conclusion It was concluded that the β TCP/BMP artificial bone can be used in GTR technique to promote periodontal regeneration.

关 键 词：骨形成蛋白 βTCP/BMP 牙周组织再生 人工骨 

分 类 号：R781.4[医药卫生—口腔医学]