瑞芬太尼复合丙泊酚在小儿先天性唇腭裂修复手术中的应用价值研究  

The research of the value for remifentanil and propofol in children with congenital cleft lip and palate repair surgery

作　　者：刘卫校 

机构地区：[1]河南省许昌市中心医院麻醉科,河南许昌461000

出　　处：《现代预防医学》2013年第5期850-851,854,共3页Modern Preventive Medicine

摘　　要：目的探讨瑞芬太尼复合丙泊酚在小儿先天性唇腭裂修复手术中的应用价值。方法选取小儿先天性唇腭裂修复手术患儿80例,随机分为两组,其中对照组38例,观察组42例,使其各方面均有可比性。对照组患儿给予羟丁酸钠联合氯胺酮麻醉;观察组患儿给予瑞芬太尼联合丙泊酚麻醉。对两组患儿麻醉诱导以后至手术结束时平均动脉压(mean arterial pressure,MAP)及心率进行监测和记录,统计两组患儿术后拔管时间及出手术室时间,以及苏醒期躁动和恶心呕吐发生率。结果麻醉诱导开始以后直至手术结束时,观察组患儿血压和心率均明显低于对照组;观察组患者术后拔管时间以及出手术室时间均明显短于对照组,苏醒期躁动及恶心呕吐等不适发生情况均明显低于对照组。上述比较两组差异有统计学意义(P﹤0.05)。结论对先天性唇腭裂修复手术患儿实施瑞芬太尼复合丙泊酚麻醉只要进行严密观察、注意给药速度并对用量进行适当调整可以具有良好的安全性和可行性。OBJECTIVE To investigate the value for remifentanil and propofol in children with congenital cleft lip and palate repair surgery. METHODS 80 cases with congenital cleft lip and palate repair surgery were randomly divided into two groups, 38 cases of the control group, and the observation group of 42 cases, making all aspects comparable. The control group was given with sodium oxybate jointed ketamine anesthesia, and the observation group was given with remifentanil and propofol anesthesia. The control group was given with sodium oxybate jointed ketamine anesthesia. The observation group was given with remifentanil and propofol. The MAP and heart rate were taken for monitoring and recording at the end of induction of anesthesia. The postoperative extubation time and out of the operating room time, as well as the restlessness and incidence of nausea and vomiting of the two groups were taken for statistics. RESULTS After the start of the induction of anesthesia until the end of surgery, children with blood pressure and heart rate of the observation group were significantly lower than those in the control group. The extubation time as well as the operating room time after surgery in the observation group was significantly shorter than the control group, restlessness and nausea vomiting and discomfort occurrences were significantly lower than the control group. The above comparison difference between the two groups had statistically significance （P 〈 0.05）. CONCLUSION The imple- mentation of remifentanil and propofol anesthesia surgery in children with congenital cleft lip and palate repair can have a good safety and feasibility with the close observation, paying attention to the speed of administration and appropriate dosage adjust- ments.

关 键 词：瑞芬太尼 丙泊酚 麻醉 先天性唇腭裂 

分 类 号：R782.054[医药卫生—口腔医学]