人宫颈癌基因对原发性肝癌的诊断价值  

The diagnostic value of serum HCCR in primary hepatic carcinoma (PHC)

作　　者：袁明生[1] 刘振海[2] 

机构地区：[1]广东省中山市陈星海医院检验科,广东中山528415 [2]广东省中山市陈星海医院肿瘤内科

出　　处：《现代预防医学》2013年第5期914-915,920,共3页Modern Preventive Medicine

基　　金：2009年中山市科技局立项(文件编号:中科发[2009]75号)(项目编号:20091A071)

摘　　要：目的评价人宫颈癌基因(HCCR)在原发性肝癌(primary hepatic carcinoma,PHC)诊断中的作用。方法分析40例原发性肝癌患者、40例慢性肝病患者与40名体检者血清中HCCR的水平,应用受试者工作特性曲线(ROC)对HCCR检测结果进行分析评价。结果①40例肝癌组HCCR浓度(136.850IU/L±74.671IU/L)高于肝病组(65.165IU/L±18.359IU/L)和对照组(71.368IU/L±16.014IU/L),差异有统计学意义(P=0.000)。②HCCR、AFP诊断原发性肝癌ROC曲线下面积分别为0.863、0.973。③在诊断原发性肝癌方面,HCCR与AFP无明显相关性(r=0.268,P=0.003)。结论 HCCR对PHC有重要的诊断价值,且与AFP无明显相关性,可作为AFP的补充诊断PHC。OBJECTIVE To study the diagnostic value of human cervical cancer oncogene （HCCR） in primary hepatic carci- noma （PHC）. METHODS The levels of serum HCCR in 40 PHC patients, 40 chronic liver disease patients the and 40 healthy persons were retrospectively analyzed. The results of HCCR were analyzed and evaluated by ROC curve. RESULTS ①The level of serum HCCR in patients with PHC （ 136.850IU/L ＋ 74.6711U/L） was significantly higher than that of chronic liver disease patients （65.165IU/L ＋ 18.359IU/L） （P = 0.000） and healthy persons （71.368IU/L ＋ 16.014 IU/L） （P = 0.000）. ②The area under ROC curve in diagnosis of PHC with HCCR and AFP was 0.863, 0.973 respectively. ③There were no significant corre- lations between HCCR and AFP （r = 0.268, P = 0.003）. CONCLUSION HCCR is helpful for the diagnosis of PHC. There are no significant correlations between HCCR and AFP and HCCR is one of serum tumor marker in the diagnosis of PHC.

关 键 词：人宫颈癌基因 原发性肝癌 ROC曲线 诊断 

分 类 号：R735.7[医药卫生—肿瘤]