风湿宁胶囊中挥发油的提取及包合工艺优选  

Optimization of Extraction and Inclusion Technology for Volatile Oil from Anti-rheumatism Capsules

作　　者：岳晓华[1] 段秀俊[1] 史利霞[1] 王永辉[1] 薛慧清[1] 张海 周然[1] 

机构地区：[1]山西中医学院,太原030024 [2]山西仁源堂药业有限公司,太原030043

出　　处：《中国实验方剂学杂志》2013年第5期22-24,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技重大专项重大新药创制项目(2010ZX09102-210);山西省科技产业化环境建设项目(2012061014-3)

摘　　要：目的:优选风湿宁胶囊中挥发油的提取与包合工艺。方法:采用水蒸气蒸馏法提取挥发油,以提取量为指标,通过单因素试验考察加水量、提取时间对提取工艺的影响;采用饱和水溶液法包合挥发油,以包合率为指标,通过正交试验考察挥发油与β-CD的比例、包合时间及包合温度对包合工艺的影响。结果:最佳提取工艺为加14倍量水提取4 h;最佳包合工艺为挥发油与β-环糊精的比例1∶8,包合温度40℃,包合时间3 h。结论:优选的挥发油提取与包合工艺条件稳定可行。Objective：To optimize extraction and inclusion technology of volatile oil from anti-rheumatism capsules. Method： Volatile oil was extracted by steam distillation method,with yield of volatile oil as index,effect of water amount and extraction time on extraction technology was investigated by single factor test;Volatile oil was inclused by saturated aqueous solution method using inclusion ratio as index,orthogonal test was used to optimize inclusion technology with ratio of volatile oil to β-cyclodextrin,inclusion time and temperature as factors. Result： Optimum extraction conditions were：extracted 4 h with 14 times the amount of water;Optimal inclusion technology was as followings：ratio of volatile oil to β-cyclodextrin 1∶8,inclusion tempemture 40 ℃,inclusion time 3 h. Conclusion： These optimized extraction and inclusion technology conditions were reasonable and feasible.

关 键 词：风湿宁胶囊 挥发油提取 Β-环糊精 包合工艺 

分 类 号：R283.6[医药卫生—中药学]