宫颈细胞DNA倍体分析与液基细胞学联合HPV检测宫颈癌前病变的临床应用价值  

Clinical application values of DNA ploidy analysis of cervical cells and Thinprep cytologic test combined with HPV detection for diagnosis of cervical precancerous lesion

作　　者：陈广莉[1] 徐又先[1] 李立[1] 杨岚[1] 

机构地区：[1]广西柳州市人民医院妇科,545006

出　　处：《中国妇幼保健》2013年第7期1179-1181,共3页Maternal and Child Health Care of China

摘　　要：目的:比较细胞DNA倍体分析技术与宫颈液基细胞学联合HPV DNA检测在宫颈癌前病变诊断中的应用价值。方法:将1 068例门诊患者随机分为2组,分别进行细胞DNA倍体分析或宫颈液基细胞学联合HPV DNA检测,比较两种检测方案检测宫颈癌前病变的准确性。结果:检测阳性率细胞DNA倍体分析组为7.68%,宫颈液基细胞学联合HPV检测组为6.93%,两组比较差异无统计学意义(P>0.05)。以CINⅠ为癌前病变标准,细胞DNA倍体分析组筛查阳性的病例癌前病变符合率为75.61%,宫颈液基细胞学联合HPV检测组为54.05%,两组比较差异有统计学意义(P<0.05)。结论:细胞DNA倍体分析与宫颈液基细胞学联合HPV检测对宫颈病变的筛查阳性率接近,但DNA倍体分析筛查CIN的准确性更高。Objective： To compare the clinical application values of DNA ploidy analysis of cervical cells and Thinprep cytologic test combined with HPV detection for diagnosis of cervical precancerous lesion. Methods： A total of 1 068 patients from outpatient department of the hospital were randomly divided into two groups, then the patients in the two groups received DNA ploidy analysis of cervical cells and Thinprep cytologic test combined with HPV detection, respectively ; the accuracies of the two methods for diagnosis of cervical precancer- ous lesion were compared. Results： The positive rates in DNA ploidy analysis group and joint detection group were 7.68% and 6. 93% , re- spectively, there was no statistically significant difference between the two groups （ P 〉 0. 05 ） . Taking cervical intraepithelial neoplasia （CIN） I as the criterion of cervical precancerous lesion, the coincidence rates in DNA ploidy analysis group and joint detection group were 75.61% and 54. 05% , respectively, there was statistically significant difference between the two groups （P 〈 0. 05 ） . Conclusion： The positive rates of DNA ploidy analysis and joint detection for screening cervical lesions are approximate, but the accuracy of DNA ploidy analy- sis for screening CIN is higher.

关 键 词：细胞DNA倍体分析 液基细胞学 宫颈病变 

分 类 号：R737.33[医药卫生—肿瘤]