PVDF中空纤维膜改性研究(2)表面接枝两性离子制备抗污染性电解质响应PVDF中空纤维膜  

Study on the modification of PVDF hollow fiber membrane (2) An anti-protein-fouling and electrolyte-sensitive PVDF hollow fiber membrane prepared with zwitterionic polymer viasurface grafting

作　　者：李倩[1] 周波[1] 毕秋艳[1] 肖燕[1] 王晓琳[1] 

机构地区：[1]清华大学化学工程系膜材料与工程北京市重点实验室,北京100084

出　　处：《膜科学与技术》2013年第1期33-38,61,共7页Membrane Science and Technology

基　　金：国家重点基础研究发展计划项目(973计划;2009CB623401);国家高技术研究发展计划资助项目(863计划;2009AA062901;2012AA03A604);北京市自然科学基金重大项目(2100001)

摘　　要：利用化学引发原子自由基聚合(ATRP)方法,将两性离子3(甲基丙烯酰胺)丙基二甲基(3磺丙)胺(MPDSAH)接枝于聚偏氟乙烯(PVDF)中空纤维膜外表面,获得具有抗污染性能的电解质响应膜(PVDF-g-polyMPDSAH).随着接枝量的增加,表面改性PVDF膜的亲水性提高,蛋白质吸附量减少.改性PVDF膜的在过滤实验中显示出较好的抗污染性能.PVDF-g-polyMPDSAH膜的蛋白质吸附量随着溶液中NaCl浓度的增加而大幅降低.Na+和Cl-渗入polyMPDSAH支链亦会屏蔽MPDSAH正负偶极的相互作用,导致polyMPDSAH溶胀堵塞膜孔,减小膜的渗透通量.因此,PVDF-g-polyMPDSAH表面与蛋白质的相互作用及其电解质响应性使膜的渗透性得到了智能化地控制.这为两性离子改性PVDF中空纤维膜在蛋白质分离和净化等生物医药领域提供了更广泛的应用前景.A zwitterionic monomer, 3-（methacryloylamino） propyl-dimethyl-（3-sulfopropyl） ammonium hydroxide （MPDSAH） was successfully grafted from the outside surface of poly （vinylidene fluoride） （PVDF） hollow fiber membrane via chemical activation and atom transfer radical polymerization （ATRP） and an anti-protein-fouling and electrolyte-sensitive PVDF membrane was obtained. The surface hydrophilicity of the modified PVDF membranes was significantly enhanced with the increase of the grafting amount. The polyMPDSAH-g-PVDF membrane efficiently resisted to the adsorption of protein and showed excellent anti-protein-fouling performance during the cyclic filtration. As the NaC1 content inprotein solution increased, the protein adsorption and the permeation flux of polyMPDSAH-g-PVDF mem- brane decreased greatly because Na＋ and Cl- entered the chains of polyMPDSAH and shielded the interac- tion of positive dipole with negative dipole in the MPDSAH molecules. Therefore, the electrolyte-sensitiv- ity of the zwitterionic-modified PVDF membrane contributed to the preparation of smart membrane, which has potentials in the field of biological medicine such as protein separation and purification.

关 键 词：两性离子 聚偏氟乙烯膜 抗污染性 电解质响应性 表面接枝 

分 类 号：TQ320.721[化学工程—合成树脂塑料工业]