Structural insight into substrate recognition by histone demethylase LSD2/KDM1 b  

作　　者：Fei Chen Huirong Yang Zhenghong Dong Jian Fang Ping Wang Tingting Zhu Wei Gong Rui Fang Yujiang Geno Shi Ze Li Yanhui Xu 

机构地区：[1]Institute of Biomedical Sciences [2]Cancer Institute, Shanghai Cancer Cen-ter, Department of Oncology, Shanghai Medical College, Fudan Univer-sity, Shanghai 200032,China [3]State Key Laboratory of Genetic Engineer-ing, School of Life Sciences, Fudan University, Shanghai 200433, China [4]Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Department of Biological Chemistry & Molecular Pharma-cology, Brigham and Women 's Hospital, Boston, MA 02115, USA

出　　处：《Cell Research》2013年第2期306-309,共4页细胞研究（英文版）

基　　金：We thank staff members of beamline BL17U at SSRF （Shang-hai Synchrotron Radiation Facility, China） for assistance in data collection, and staff members of Biomedical Core Facility, Fudan University for their help on mass spectrometry analyses. This work was supported by grants from the National Basic Research Program of China （2011CB965300 and 2009CB918600）, the Na-tional Natural Science Foundation of China （31270779, 31030019, 11079016 and 30870493）, and Fok Ying Tung Education Founda- tion （20090071220012）. This work was also supported by a grant from the National Institutes of Health （5 R01 GM078458） to YGS.

摘　　要：Dear Editor, Histone methylation is a reversible histone post-translational modification that plays an important role in various chromatin-based processes, including chromatin structure remodeling, transcription, and DNA repair [1, 2]. LSD1 （also known as KDM1A） is the first identi- fied histone lysine demethylase. It converts mono-or di-methylated histone H3 （H3K4mel/me2） to unmodified H3 [3].

关 键 词：组蛋白甲基化 结构洞 染色质结构 识别 底物 翻译后修饰 DNA修复 组蛋白H3 

分 类 号：Q52[生物学—生物化学] TU398.2[建筑科学—结构工程]