α干扰素在肝细胞癌治疗中的作用  

The role of interferon α in the treatment of hepatocellular carcinoma

作　　者：王鲁[1,2] 赵一鸣[1,2] 张宁[1,2] 周嘉敏[1,2] 王龙蓉[1,2] 王苗[1,2] 汤钊猷[1,2] 樊嘉[1,2] 

机构地区：[1]复旦大学肝癌研究所 [2]复旦大学附属中山医院肝外科 癌变与侵袭原理教育部重点实验室,上海200032

出　　处：《上海医药》2013年第4期12-16,共5页Shanghai Medical & Pharmaceutical Journal

基　　金：国家自然科学基金面上项目(No.30973499;No.81272393);国家科技重大专项(No.2008ZX10002-026)

摘　　要：干扰素是一种具有广泛生物学活性的细胞因子,不仅具有抗病毒作用,而且具有增强机体抗肿瘤免疫反应、抑制肿瘤血管生成、抗细胞增殖以及诱导细胞分化、凋亡等作用。干扰素家族包括α,β,γ三类,大量研究结果显示,α干扰素可以预防慢性病毒性肝炎患者中肝癌的发生,并且具有推迟肝细胞癌术后复发及抗肝癌侵袭和转移的作用,在临床实践中有着广泛的应用。Interferon is a cytokine with a wide range of biological activity, which has not only the antiviral activity, but also the roles of enhancing the body＇s anti-tumor immune response, inhibiting tumor angiogenesis, anti-proliferation and inducing differentiation and apoptosis. The interferon family includes three categories of α,β, and γ. A large number of studies have shown that interferon α can prevent the occurrence of liver cancer in patients with chronic viral hepatitis, and has the roles of postponing liver cancer recurrence after surgical resection and inhibiting hepatocellular carcinoma invasion and metastasis, which has a wide application in clinical practice.

关 键 词：干扰素 肝细胞癌 治疗 

分 类 号：R735.7[医药卫生—肿瘤]