IL-1基因多态性与牙周炎合并2型糖尿病的关系  

Association of polymorphisms with periodontitis in Type 2 diabetes mellitus

作　　者：卢怡[1] 施生根[1] 牛忠英[1] 包博[1] 冯凯[2] 许樟荣[3] 

机构地区：[1]解放军306医院口腔科全军疾病诊治中心,北京100101 [2]解放军306医院中心实验室,北京100101 [3]解放军306医院内分泌科,北京100101

出　　处：《北京口腔医学》2013年第1期33-36,共4页Beijing Journal of Stomatology

基　　金：全军科学技术研究"十一五"计划专项课题(06Z003)

摘　　要：目的研究炎症因子单核苷酸多态性与中国2型糖尿病患者牙周炎易感性的关系。方法解放军第306医院口腔中心和糖尿病中心分别对120例单纯2型糖尿病患者、110例2型糖尿病伴发牙周炎患者进行调查,内容包括年龄、性别、全身病史、牙周病史、病程、吸烟史等,通过聚合酶链式反应--限制性片段长度多态性方法进行白细胞介素细胞因子-1β+3594基因位点单核苷酸多态性分析。结果实验组和对照组的年龄、性别等一般资料数据均衡检验无差异。基因多态性分析表明,实验组IL-1β+3954 C等位基因的频率较对照组无显著差异无统计学意义。结论 IL-1β+3954等位基因与中国人2型糖尿病患者的牙周炎易感性无显著关系。Objective To investigate the possible relationship between polymorphism and the periodontitis with type 2 diabetics. Methods A total of 120 diabetics and 110 diabetics with periodontitis were enrolled in this study. Documented information included patient age, gender, medical history findings, periodontal history and use of tobacco products. Single nucleotide polymorphisms （SNPs） at interleukin-1 （ IL-1 ） 13 ＋ 3954 were analyzed by standard polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） assay. Results The frequency of IL-113 ＋ 3954 C gene type was not significantly increased in periodontitis group compared to controls. Conclusion IL-113 ＋ 3954 polymorphism was not related to periodontitis susceptibility in Chinese Type 2 diabetes mellitus.

关 键 词：牙周炎 糖尿病 白细胞介素细胞因子-1 单核苷酸多态性 

分 类 号：R781.4[医药卫生—口腔医学]