源于牙源性角化囊性瘤的鳞状细胞癌(5例报道)  

Squamous cell carcinoma arising from keratocystic odontogenic tumors(a review of five cases)

作　　者：张军[1] 陈瑞杨[2] 许振起[1] 

机构地区：[1]天津市口腔医院口腔颌面外科,天津300041 [2]天津市口腔医院病理科,天津300041

出　　处：《北京口腔医学》2013年第1期47-49,共3页Beijing Journal of Stomatology

摘　　要：目的探讨源于牙源性角化囊性瘤(keratocystic odontogenic tumors,KCOT)的鳞状细胞癌(SCC)的临床诊断及治疗。方法回顾5例由KCOT发展为SCC的患者病史,观察并记录每位患者的临床及影像学表现、治疗过程、组织病理表现及预后情况。结果 5例患者因KCOT接受治疗,在由KCOT转变为SCC期间,主要为反复肿胀及疼痛,放射透射病变区范围扩大。病理上,所有患者由先前存在的伴有不全角化上皮的多囊性KCOT进展到具有典型病理表现的SCC。5例患者随访期间均死亡。结论源于KCOT的SCC虽然罕见,但临床上不能忽视。长期严密观察、常规检查以及连续的影像学检查及活检可能有助于疾病的早期发现、早期诊断。Objective To discuss the clinical diagnosis and treatment of squamous cell carcinoma arising （SCC） from keratoeystic odontogenic tumors （KCOT）. Methods Five patients with SCC that developed from KCOT were reviewed. The clinical and radiographic manifestation, therapy, histopathology and the results of prognosis were observed and recorded for each patient. Results Five patients were originally treated for KCOT. During the follow-up period when keratocystic odontogenic tumor developed to SCC, repeated swelling and pain were reported and radiolucency area enlarged. All cases progressed from preexisting polycystic KCOT with parakeratinized epithelium to SCC with typical pathological presentation. All five patients died during the follow-up. Conclusion In KCOT cases, close follow-up, physical examinations accompanied with serial radiographic imaging and biopsy may contribute to early detection and diagnosis of malignant transformation.

关 键 词：鳞状细胞癌 牙源性角化囊性瘤 恶变 

分 类 号：R739.81[医药卫生—肿瘤]