重组人表皮生长因子促进角膜上皮损伤修复的研究  

The research of recombinant human epidermal growth factor on enhancing corneal epithelial defect healing

作　　者：林跃生[1] 王敏华[1] 陈家祺[1] 陈龙山[1] 

机构地区：[1]广州中山医科大学中山眼科中心,510060

出　　处：《中国实用眼科杂志》2000年第11期700-703,共4页Chinese Journal of Practical Ophthalmology

摘　　要：目的 :客观评估重组人表皮生长因子 (rh EGF)促进角膜上皮损伤修复的临床疗效及安全性。方法 :应用前瞻性评估研究方法 ,对无角膜缘干细胞异常的角膜盲 15 3例 15 3只眼施行穿透性角膜移植术。移植片直径统一为 7.5 mm,术中去除供体角膜上皮 ;将所有研究病例按随机双盲原则分试验组 (91眼 )、赋型剂组 (31眼 )及素高捷疗组 (31眼 )。术后分别观察移植片角膜上皮的愈合速率。结果 :各 rh EGF组术后移植片角膜上皮愈合时间比赋型剂组及素高捷疗组明显缩短 (t检验 ,P<0 .0 1)。结论 :rh EGF滴眼液能有效促进角膜上皮损伤的修复 ,其临床最佳安全浓度为 2Purpose:To evaluate objectively the clinical efficacy and safety of recombinant human epidermal growth factor(rhEGF)on enhancing corneal epithelial defect healing.Methods:A prospective,random study was carried out.The 153 corneal blindness cases (153 eyes)with limbal normality were treated by penetrating keratoplasty in which each graft measured 7 5mm in diameter and all donor epithelia were removed during operation.All the 153 cases were randomly divided into ecperimental groups(91 eyes)treated by rhEGF eyedyops,positive control group (31 cases)treated by Solcoseryl Eye Gel,and negative group (31 cases)treated by vehicle.The healing rates of corneal epithelium were observed postoperation.Results:Time until epithelium defect healing was significantly shorter with rhEGF compared with vehicle group (P<0 01)and Solcoseryl Eye Gel group (P<0 01).Conclusion:The results indicated that rhEGF improved effectively the healing of corneal epithelial defect.The clinical optimal safety concenration is 20μg/ml.

关 键 词：角膜上皮细胞损伤 角膜移植 RHEGF 

分 类 号：R772.205[医药卫生—眼科] R779.65[医药卫生—临床医学]