结肠癌根治术后复发的危险因素分析  

Risk factors of postoperative recurrence after radical resection of colon cancer

作　　者：王越[1] 侴伟平[1] 沈春键[2] 王晓宇[2] 罗蓟[3] 

机构地区：[1]辽宁省肿瘤医院麻醉科,辽宁沈阳110042 [2]沈阳医学院沈洲医院外科,辽宁沈阳110002 [3]中国医科大学附属第一医院普通外科,辽宁沈阳110001

出　　处：《大连医科大学学报》2013年第1期65-67,共3页Journal of Dalian Medical University

摘　　要：目的探讨结肠癌根治术后复发的因素。方法选取1995年1月—2009年1月行根治术的结肠癌患者193例中获随访并且资料完整的165例作为研究对象。选择对结肠癌术后复发可能产生影响的临床因素,通过Cox比例风险模型进行多因素分析。结果全组复发率为16.36%(27/165)。单因素分析显示,淋巴结转移、肿瘤大小、Dukes’分期和肿瘤细胞分化程度与结肠癌根治术后肿瘤复发有关。多因素分析显示,淋巴结转移和肿瘤细胞分化程度是结肠癌根治术后肿瘤复发的独立危险因素。结论肿瘤细胞分化程度是结肠癌根治术后复发最重要的预后因素,而淋巴结转移是根治术后复发重要的预后因素。Objective To discuss the independent prognostic factors influencing long- term survival rate of the patients with colon cancer after radical resection. Methods Univariate and Cox multivariate regression analysis was performed on 165 patients treated with radical resection from Jan. 1995 to Jan. 2009. Results The overall recurrence was 16.36%. Uni- variate analysis showed that lymph node involvement, tumor size, Dukes＇stage and histological differentiation were correla- ted to recurrence of colon cancer after operation ; Multivariate analysis showed that lymph node invo]vement and histological differentiation were significant factors for recurrence rate of colon cancer. Conclusions Histological defferentiation is the most important prognositc factor for patients with colon cancer after radical resection, whereas lymph node metastasis is an important nrognostic factor.

关 键 词：结肠癌 根治术后 肿瘤复发 淋巴结转移 危险因素分析 

分 类 号：R735.35[医药卫生—肿瘤]