一氧化氮和腺苷联合治疗幼猪急性缺氧性肺动脉高压  

Combined use of nitric oxide and adenosine in the treatment of piglets with pulmonary hypertension induced by acute hypoxia in piglets

作　　者：徐卓明[1] 陈玲[1] 苏肇伉 史珍英[1] 俞晓青[1] 杨艳敏[1] 丁文祥[1] 

机构地区：[1]上海第二医科大学附属新华医院外科,200092 [2]上海儿童医学中心小儿心胸外科

出　　处：《中华实验外科杂志》2000年第6期507-508,共2页Chinese Journal of Experimental Surgery

摘　　要：目的　观察联合使用一氧化氮 (NO)和腺苷 (AD)对肺动脉高压的影响。方法　选用上海种白猪 10头 ,建立急性缺氧性肺动脉高压模型 ,采用分别使用吸入NO 2 0× 10 -6和静脉持续每分钟滴注AD 5 0 μg/kg体重 ,以及联合使用NO和AD的方式 ,在各时段进行各项血流动力学指标测定。结果　联合使用NO和AD ,平均肺动脉压力从 (37± 7)mmHg(1mmHg =0 .133kPa)降至 (2 0± 1)mmHg(P <0 .0 1) ,心排指数从 (2 .30± 0 .5 0 )L·min-1·m-2 升至 (2 .76± 0 .46 )L·min-1·m-2 (P <0 .0 5 )。结论　NO和AD联合治疗幼猪急性缺氧性肺动脉高压 ,在降低肺动脉压力的同时 ,还可增加心输出量。Objective\ To investigate the effects of the combined use of nitric oxide (NO) and adnosine (AD) on pulmonary hypertension. Methods\ Ten mechanically ventilated piglets with pulmonary hypertension induced by acute hypoxia were studied. Hemodynamic data were measured during the combined use of inhaled NO (20×10 -6 ) and constant intravenous infusion of AD (50 μg·kg -1 ·min -1 ). Results\ Combined use of inhaled NO and constant intravenous infusion of AD could significantly decrease mean pulmonary artery pressure (MPAP) from (37±7) mm Hg to (20±1) mm Hg (1 mm Hg=0.133 kPa) ( P <0.01) , and increase cardiac index (CI) from (2.30±0.50) L·min -1 ·m -2 to (2.76±0.46) L·min -1 ·m -2 ( P <0.05). Conclusion\ Combined use of inhaled NO and constant intravenous infusion of AD could decrease MPAP and increase CI in acute hypoxia induced pulmonary hypertension piglets.\;

关 键 词：一氧化氮 腺苷 急性缺氧性肺动脉高压 联合治疗 

分 类 号：R363[医药卫生—病理学]