GIRK4基因在肥胖大鼠肾脏组织的表达  

Expression of GIRK4 Gene in Kindey Tissues of Obese Rat

作　　者：康永安[1] 胡燕荣[1] 高莉[1] 杨海[1] 李南方[1] 

机构地区：[1]新疆维吾尔自治区人民医院高血压中心新疆高血压研究所,乌鲁木齐830001

出　　处：《中国医学科学院学报》2013年第1期36-39,共4页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(81160109)~~

摘　　要：目的研究GIRK4基因在正常与肥胖大鼠肾脏组织表达水平的差异。方法采用饮食诱导的方法构建肥胖大鼠模型,Western blot技术对正常组与肥胖组大鼠肾脏组织GIRK4蛋白表达进行定量分析。结果肥胖组大鼠肾脏组织GIRK4蛋白相对表达量为1.75±0.42,明显低于正常组大鼠的3.37±0.68(P<0.05)。结论肥胖大鼠肾脏组织GIRK4蛋白表达降低。Objective To investigate the expression of GIRK4 gene in the kidney tissues of obese rats. Methods Obese rat models were established using diet-induced method. The GIRK4 protein expression in kidney tissues was determined in 20 obese rats and 10 normal rats using Western blot analysis. Results The relative expression level of GIRK4 protein in the kidney tissues of obese rat （ 1.75± 0.42 ） was significantly lower than that in normal rats （3.37 ± 0.68, P 〈 0.05 ）. Conclusion GIRK4 has a low protein expression in the kidney tissues of obese rat.

关 键 词：GIRK4基因 大鼠 肾脏组织 

分 类 号：R394.3[医药卫生—医学遗传学]