尼古丁乙酰胆碱受体在烟草相关癌症中的研究进展  

Nicotinic acetylcholine receptor in tobacco-related cancer

作　　者：贾颖[1] 祖珊珊[1] 马晓丽[1] 

机构地区：[1]山东大学附属济南市中心医院中心实验室,济南市250013

出　　处：《中国肿瘤临床》2013年第4期236-238,共3页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金项目(编号:81272588);山东省自然科学基金项目(编号:ZR2012 HM061)资助~~

摘　　要：目前,每年吸烟可引起大约5～6百万人死亡,其中吸烟引起的癌症死亡占所有癌症死亡总数的30%以上。烟草中的成瘾成分尼古丁和其衍生的致癌物质亚硝胺可以通过激活尼古丁乙酰胆碱受体(nicotinic acetylcholine receptor,nAChRs)而导致癌症的发生。尼古丁在支气管上皮细胞可通过氧化应激反应而引起DNA损伤,此外,尼古丁可诱发肿瘤的发生,但其在致癌方面的作用尚不明确。本文就近几年nAChRs与烟草相关癌症发生、发展的研究进展进行综述。Tobacco smoking results in the death of approximately 5 to 6 million people in the world each year, including more than 35% of total cancer deaths. Nicotine, the addictive constituent of tobacco, as well as its derived carcinogenic nitrosamines contribute to cancer progression through the activation of the nicotinic acetylcholine receptor （nAChRs）. The role of nicotine in carcinogenesis remains controversial; nicotine has been proven to induce DNA damages by oxidative stress induction in bronchial epithelial cells. Moreover, nicotine induces myosarcomas in the A/J strain of mice. The advances on nAChRs in tobacco-related cancer were briefly summarized in this review.

关 键 词：烟草相关的癌症 尼古丁 尼古丁乙酰胆碱受体 肺癌 

分 类 号：R730.2[医药卫生—肿瘤]