原发性失眠患者的血清P物质水平及其影响因素  

Serum level of substance P and related factors in patients with primary insomnia

作　　者：黄俏庭[1] 刘亚平[1] 廖继武[1] 石顺治[1] 马萍[1] 潘集阳[1] 

机构地区：[1]暨南大学附属第一医院精神科,广州510630

出　　处：《中国神经精神疾病杂志》2013年第2期65-69,共5页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的探讨原发性失眠患者血清P物质(substance P,SP)水平及其影响因素。方法收集原发性失眠患者46例(患者组)及睡眠正常的健康对照42例(对照组),采用匹兹堡睡眠质量指数问卷(Pittsburgh Sleep Quality Index,PSQI)、状态特质焦虑问卷(State-Trait Anxiety Inventory,STAI)和贝克抑郁问卷(Beck Depression Inventory,BDI)评定受试者的主观睡眠状况及焦虑、抑郁水平,以酶联免疫吸附法对受试者血清SP含量进行测定。采用独立样本t检验比较两组血清SP水平,并采用线性回归分析所有受试者血清SP水平的影响因素。结果患者组血清SP水平高于对照组([6.68±3.10)ng/mL vs(.5.27±2.49)ng/mL],差异有统计学意义(P<0.05)。单因素线性回归分析中,血清SP与PSQI总分(β=0.143,P<0.05)、BDI总分(β=0.116,P<0.05)分别呈正关联;与性别、年龄、体重指数、病程及SAI、TAI总分无统计学相关性(均P>0.05)。多因素回归分析显示,仅PSQI总分为血清SP水平的影响因素(β=0.143,P<0.05)。结论原发性失眠患者存在外周血SP水平紊乱,SP可能参与了原发性失眠的发病机制。Objective To explore the serum level of substance P （SP） in patients with primary insomnia and its related factors. Methods A total of 46 patients with primary insomnia and 42 healthy controls with normal sleep were enrolled in our study. The Pittsburgh Sleep Quality Index （PSQI）, State-Trait Anxiety Inventory （STAI）, and Beck Depression Inventory （BDI） were used to assess the subjective sleep quality and the levels of anxiety and depression. The serum SP concentrations of all subjects were determined by enzyme-linked immuno sorbent assay. Student＇ s t-test was used to compare the SP levels between two groups; linear regression was used to analyze the affecting factors of all subjects＇ SP level. Results The serum SP levels in patients were significantly higher than those in controls [（6.68±3.10） ng/mL vs. （5.27±2.49） ng/mL, P〈0.05]. In simple linear regression, scores of PSQI （β= 0.143, P〈0.05） and BDI （β=0.116, P〈0.05） were significantly and positively correlated with the serum SP levels respectively in all subjects, while gender, age, body mass index, course of insomnia and the scores of SAI and TAI were not significantly correlated with the serum SP levels in all subjects （P〉0.05）. Multiple linear regression analysis showed that only score of PSQI significantly affected individuals＇ serum SP level （β=0.143, P〈0.05）. Conclusion The results suggest that there is a disturbance of serum SP level in patients with primary insomnia. SP may involve in the pathophysiological progress of primary insomnia.

关 键 词：原发性失眠症 P物质 睡眠质量 

分 类 号：R740[医药卫生—神经病学与精神病学]