Ⅲ期非小细胞肺癌的综合治疗  

Multimodality treatment of stage Ⅲ non-small cell lung cancer

作　　者：刘江泽[1] 黄原义[1] 魏嵬[1] 熊远奎[1] 廖欣彬[1] 李英[1] 

机构地区：[1]湖北省荆州市中心医院放射科,湖北荆州434020

出　　处：《中国中西医结合影像学杂志》2013年第1期34-36,39,共4页Chinese Imaging Journal of Integrated Traditional and Western Medicine

摘　　要：目的:探讨支气管动脉化疗栓塞结合同步放疗、静脉化疗治疗Ⅲ期非小细胞肺癌(NSCLC)的疗效。方法:143例Ⅲ期NSCLC患者分为2组,对照组71例,化疗与放射治疗同步进行;介入组72例,采用支气管动脉化疗栓塞,第2天行放疗,介入治疗2个周期。放疗总剂量60～70Gy,6～7周完成。所有患者3～4周后采用长春瑞滨、顺铂(NP)方案,共化疗2～4个周期。结果:2组全部完成治疗计划。介入组完全缓解(CR)占37.5%,部分缓解(PR)占45.8%,有效率83.3%;对照组CR占23.9%,PR占39.4%,有效率63.3%。介入组中位生存期为22.6个月,对照组为14.5个月。1、2、3年生存率介入组为78.6%、44.3%、23.5%,对照组为63.2%、33.4%、14.5%。介入组明显高于对照组,差异有统计学意义(P<0.05)。无严重并发症发生。结论:经支气管动脉化疗栓塞结合放疗、静脉化疗治疗Ⅲ期NSCLC能延长患者的中位生存期,提高生存率,具有较好的临床疗效。Objective： ：To investigate the effect of bronchial artery chemoembolization combined with radiotherapy, chemother apy for stage Ⅲ non-small cell lung cancer （NSCLC）. Methods： 143 cases of NSCLC were divided into two groups. In group of chemotherapy and radiotherapy, 71 cases had chemotherapy and radiation therapy synchronously. The intervention group of 72 cases with bronchial artery infusion chemotherapy and embolization had interventional radiotherapy on the second day for 2 cy cles. Total dose of radiotherapy was 60-70 Gin6-7 weeks. 3 to4 weeks after, all patients used NP program, with a total of 2 to 4 cycles of chemotherapy. Results： Two groups completed treatment plan. The intervention group had CR 37.5%, PR 45.8%, efficiency 83.3%. The control group had CR 23.9%, PR 39.4%, efficiency 63.3%. In the intervention group, medi an survival time was 22.6 months, and it was 14.5 months in the control group. In the intervention group, 1, 2, 3 year survival rate was 78.6%, 44.3%, 23.5%, respectively. And, in control group, it was 63.2%, 33.4%, 14.5%, respeetively. The intervention group was significantly higher than that in the control group, there was significant difference （ P〈0.05）. No se rious complications occurred. Conclusion：Percutaneous bronchial artery chemoembolization combined with radiotherapy, chemotherapy in treatment of stage Ⅲ NSCLC can prolong median survival time, improve the survival rate of patients, have good clinical efficacy.

关 键 词：癌 非小细胞肺 抗肿瘤联合化疗方案 放射治疗 计算机辅助 化学栓塞 治疗性 

分 类 号：R734.2[医药卫生—肿瘤] R815[医药卫生—临床医学]