单胺氧化酶A基因单核苷酸多态性与特质怒的关联性分析  

Study on association between single nucleotide polymorphism of monoamine oxidase A gene and trait anger

作　　者：闫秀娟[1] 詹向红[1] 刘永[1] 李伟 侯俊林[1] 闫国立[1] 王淑玲[2] 王友杰[1] 杨丽萍[1] 

机构地区：[1]河南中医学院,郑州450034 [2]郑州大学医学院,郑州450052

出　　处：《中华中医药杂志》2013年第3期775-777,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.30772686;No.30973695)~~

摘　　要：目的:研究单胺氧化酶A(MAOA)基因单核苷酸多态性(SNP)与特质怒的关系。方法:根据状态特质愤怒表达量表2(STAXI-2)特质怒得分筛选受试者,经采血、酚-氯仿法提取DNA、PCR-LDR法对MAOA基因上的4个标签单核苷酸多态性(Tag SNP)位点进行基因分型,对相关数据进行统计分析。结果:MAOA基因中4个Tag SNP位点的基因型和等位基因频率在高、低特质怒组间的差异无统计学意义。结论:MAOA基因单核苷酸多态性与国内正常大学生特质怒无显著相关性。Objective： To investigate the association between single nucleotide polymorphism （SNP） of monoamine oxidase A gene（MAOA） and trait anger（T-Ang）. Method： Healthy college students were investigated with the state-trait anger expression inventory 2（STAXI-2）. Four tag SNP of MAOA were genetic typed by PCR-based ligase detection reaction（PCR- LDR）, then we used the SPSS13.0 software for statistical analysis. Results： There were no significant difference in genotype and allel frequency of the four tag SNP between the high and low trait anger group. Conclusion： There is no significant correlation between MAOA gene single nucleotide polymorphisms and trait-anger of China normal university students.

关 键 词：特质怒 单胺氧化酶A 标签单核苷酸多态性 

分 类 号：R228[医药卫生—中医基础理论]