益气养阴解毒方影响鼻咽癌患者放化疗后康复过程的临床疗效观察  

Clinical observation on the therapeutic effects of Qi-Boosting Yin-Enriching Toxin-Resolving Formula on the rehabilitation course of patients with nasopharyngeal carcinoma treated by radiochemotherapy

作　　者：李梅芳[1] 余丽亚[1] 吴新正[1] 邓宇元[1] 刘刚[1] 田道法[2] 

机构地区：[1]湖南省脑科医院耳鼻咽喉科,长沙410007 [2]湖南中医药大学中西医结合学院

出　　处：《中国中西医结合耳鼻咽喉科杂志》2013年第1期29-32,共4页Chinese Journal of Otorhinolaryngology in Integrative Medicine

摘　　要：目的观察益气养阴解毒方干预疗法对初诊鼻咽癌患者放化疗后康复过程的影响,评价其临床疗效。方法初诊鼻咽癌放疗化疗后患者65例作为观察组,予以益气解毒养阴方干预治疗;1:1配对法平行设置放化疗后常规对症治疗的初诊鼻咽癌患者65例作为对照组。收集所有患者社会人口学信息、治疗前后临床资料;随访患者康复过程,包括病灶愈合、复发或转移情况,生存时间,生活质量QOL评分,评价益气养阴解毒方干预疗法对鼻咽癌患者放化疗后康复过程的临床疗效。结果观察组和对照组QOL评分(50.25±8.60,40.80±5.63)、肿瘤复发时间(7.36±2.12,5.86±1.59)年、5年复发率(18.46%,33.85%)、10年及以上生存率(67%,43.77%)的差异比较有显著性统计学意义(P<0.05)。结论益气养阴解毒方干预疗法能够有效改善鼻咽癌患者放化疗后的QOL,延长生存期,降低复发率。Objective To investigate the therapeutic effects of intervention therapy with Qi-Boosting Yin-Enriching Toxin-Resolving Formula （QYTF） on the rehabilitation course of patients with nasopharyngeal carcinoma （NPC） treated by radiochemotherapy based on a clinical trial. Methods Sixty-five NPC cases, treated by radiochemotherapy, were included in this study and interferrd with QYTE during the period of rehabilitation as treating group （TG）. Another 65 NPC cases, treated by radiochemotherapy as well, were taken as controlling group （CG）, in a paired design way in a ratio of 1：1, and interferrd only with routine symptomatic treatment procedures during the period of rehabilitation. All the data collected before and after treatment included social demographic information and detailed clinical data for both groups of cases. Then, close following up was given to all these patients during the rehabilitation course to observe such indexes as focue healing statous, wether or not with local/region lesion relapse and distant metastasis, survival time, and scores of quality of life （QOL）. In this way, evaluated were the therapeutic effects of QYTF therapy on the rehabilitation course of NPC patients following radiochemotherapy in a comparative way with routine procedures. Results It was shouwn fi＇om this study that there were markedly statistic significance （P （0.05） in the differences of QOL scores （50.25±8.60 and 40.80±5.63）, veraged tumor recurrent time （7.36±2.12 and 5.86±1.59）, 5-year recurrent rate of lesion （18.46% and 33.85%） and survival rate of 10-year and more （67% and 43.77%） between these two groups respectively, with much much better therapeutic effects for those cases in TG. Conclusions The intervening therapy with QYTF, used in the rehabilitation course following radiochemical therapy, can significantly improve QOL, lngthen survival period and reduce recurrent rate for NPC patients.

关 键 词：鼻咽癌 益气养阴解毒方 康复治疗 疗效 

分 类 号：R739.63[医药卫生—肿瘤]