含骨缝唇腭裂颅上颌有限元模型的建立及有效性验证  

Construction and validation of a three-dimensional finite element model of cranio-maxillary complex with sutures in unilateral cleft lip and palate patient

作　　者：吴志芳[1] 雷勇华[1] 李文杰[1] 廖胜辉[2] 赵子进[3] 

机构地区：[1]中南大学湘雅医院口腔科,湖南长沙410008 [2]中南大学信息科学与工程学院,湖南长沙410083 [3]中南大学湘雅医学院,湖南长沙410013

出　　处：《上海口腔医学》2013年第1期35-40,共6页Shanghai Journal of Stomatology

基　　金：国家大学生创新性实验计划项目(YA10042)~~

摘　　要：目的:利用CT原始数据建立一个包含骨缝的唇腭裂颅上颌复合体有限元模型,并对模型的有效性进行验证,为唇腭裂颅上颌相关的生物力学研究提供一个可靠的建模依据。方法:选择1例替牙期单侧唇腭裂(unilateral cleftlip and palate,UCLP)患者进行颅面部螺旋CT扫描,利用所得CT原始数据、三维重建软件Mimics和逆向工程软件Geomagic Studio建立一个颅上颌复合体的三维几何模型,再导入Solidworks三维CAD软件中,进行颅面部12条骨缝的切割和建模,最后在自编软件中进行网格划分和赋予材料属性。模拟临床条件,在所建模型上施加上颌前牵引力,分析颅上颌各骨性结构的位移及骨缝应力分布情况,并与文献资料进行对比,验证模型的有效性。结果:建立了一个包含骨缝并具有生物力学特征的颅上颌复合体有限元模型,模型由206 753个单元和260 662个节点组成。模型的几何相似性和有效性好,可被用于相关的生物力学研究。结论:应用CT薄层扫描数据结合相关工程软件,是一种有效的建立含骨缝唇腭裂颅上颌有限元模型的方法。PURPOSE： To explore an effective method to construct and validate a finite element model of the unilateral cleft lip and palate （UCLP） craniomaxillary complex with sutures, which could be applied in further three-dimensional finite element analysis （FEA）. METHODS： One male patient aged 9 with left complete lip and palate cleft was selected and CT scan was taken at 0.75ram intervals on the skull. The CT data was saved in Dicom format, which was, afterwards, imported into Software Mimics 10.0 to generate a three-dimensional anatomic model. Then Software Geomagic Studio 12.0 was used to match, smoothen and transfer the anatomic model into a CAD model with NURBS patches. Then, 12 eircum- maxillary sutures were integrated into the CAD model by Solidworks （2011 version）. Finally meshing by E-feature Biomedical Modeler was done and a three-dimensional finite element model with sutures was obtained. A maxillary protraction force （500 g per side, 20°downward and forward from the ocelusal plane） was applied. Displacement and stress distribution of some important craniofacial structures were measured and compared with the results of related researches in the literature. RESULTS： A three-dimensional finite element model of UCLP eraniomaxillary complex with 12 sutures was established from the CT scan data. This simulation model consisted of 206 753 individual elements with 260 662 nodes, which was a more precise simulation and a better representation of human craniomaxillary complex than the formerly available FEA models. By comparison, this model was proved to be valid. CONCLUSIONS： It is an effectiveway to establish the three-dimensional finite element model of UCLP cranio-maxillary complex with sutures from CT images with the help of the following softwares： Mimics 10.0, Geomagic Studio 12.0, Solidworks and E-feature Biomedical Modeler. Supported by National University Student Innovation Experiment Project（YA10042）.

关 键 词：单侧唇腭裂 颅上颌复合体 骨缝 三维有限元模型 

分 类 号：R783.5[医药卫生—口腔医学]