吸烟对骨内种植体存留率影响的meta分析  

Influence of smoking on survival rate of endosseous implant:a meta analysis

作　　者：胡申琳[1] 陈嵩[1,2] 毛钊[1] 

机构地区：[1]南京军区南京总医院口腔科,江苏南京210002 [2]南京大学医学院,江苏南京210093

出　　处：《上海口腔医学》2013年第1期89-95,共7页Shanghai Journal of Stomatology

摘　　要：目的：评价吸烟对骨内种植体存留率的影响。方法：在PubMed、Embase及CochraneLibrary数据库中检索2012年之前发表的涉及吸烟对骨内种植体存留率影响的文献。提取符合纳入及排除标准的文献中的数据．进行meta分析。结果：共16篇文献符合纳入与排除标准，为前瞻性或回顾性队列研究。使用随机效应模型进行meta分析，结果表明，吸烟患者骨内种植体丢失的风险高于非吸烟患者（总OR为2．24，95％叫为1．66。3．01，P〈0．01），提示其存留率低于非吸烟患者。通过meta回归及亚组分析．未揭示出异质性来源。使用固定及随机效应模型相互替换、排除种植体表面特征分布不均的文献进行敏感性分析，结果无明显改变。结论：现有的有限证据表明，吸烟不利于骨内种植体的存留。本meta分析受纳入文献数量和质量所限制．其结果尚待高质量的研究予以证实。PURPOSE： To evaluate the influence of smoking on survival rate of endosseous implant. METHODS： The literatures published before the year 2012 involving influence of smoking on survival rate of endosseous implant were searched in PubMed,Embase and Cochrane databases. Data from the literatures conforming to the inclusion criteria and exclusive criteria were selected and a meta-analysis was carried out. RESULTS： Sixteen literatures conforming to the inclusion criteria and exclusive criteria were screened out, which were prospective or retrospective cohort studies. Meta analysis using random effects model showed smoking patients had higher risk to lose endosseous implants than non- smoking patients（synthesized OR 2.24,95%CI 1.66-3.01,P〈0.01）, which implied the survival rate of endosseous implant in smoking patients was lower than in non-smoking patients. Heterogeneity source was not figured out by meta regression and subgroup analysis. When sensitivity analysis was done by using fixed and random effects model alternatively or excluding articles in which the distribution of implant surface characteristics were uneven between smoking and non-smoking group, result was not changed obviously. CONCLUSIONS： The existing limited evidences show that smoking is harmful to the survival of endosseous implants. This meta-analysis is restricted by the literatures＇ quality and quantity and the results need to be confirmed by high quality studies.

关 键 词：骨内种植体 吸烟 存留率 META分析 

分 类 号：R783.6[医药卫生—口腔医学]