Methylprednisolone inhibits Nogo-A protein expression after acute spinal cord injury  

作　　者：Zhaozong Fu Hai Lu Jianming Jiang Hui Jiang Zhaofei Zhang 

机构地区：[1]Department of Spinal Surgery, Nanfang Hospital, Southern Medical University

出　　处：《Neural Regeneration Research》2013年第5期404-409,共6页中国神经再生研究（英文版）

摘　　要：Oligodendrocyte-produced Nogo-A has been shown to inhibit axonal regeneration. Methylprednisolone plays an effective role in treating spinal cord injury, but the effect of methylprednisolone on Nogo-A in the injured spinal cord remains unknown. The present study established a rat model of acute spinal cord injury by the weight-drop method. Results showed that after injury, the motor behavior ability of rats was reduced and necrotic injury appeared in spinal cord tissues, which was accompanied by increased Nogo-A expression in these tissues. After intravenous injection of high-dose methylprednisolone, although the pathology of spinal cord tissue remained unchanged, Nogo-A expression was reduced, but the level was still higher than normal. These findings implicate that methylprednisolone could inhibit Nogo-A expression, which could be a mechanism by which early high dose methylprednisolone infusion helps preserve spinal cord function after spinal cord injury.Oligodendrocyte-produced Nogo-A has been shown to inhibit axonal regeneration. Methylprednisolone plays an effective role in treating spinal cord injury, but the effect of methylprednisolone on Nogo-A in the injured spinal cord remains unknown. The present study established a rat model of acute spinal cord injury by the weight-drop method. Results showed that after injury, the motor behavior ability of rats was reduced and necrotic injury appeared in spinal cord tissues, which was accompanied by increased Nogo-A expression in these tissues. After intravenous injection of high-dose methylprednisolone, although the pathology of spinal cord tissue remained unchanged, Nogo-A expression was reduced, but the level was still higher than normal. These findings implicate that methylprednisolone could inhibit Nogo-A expression, which could be a mechanism by which early high dose methylprednisolone infusion helps preserve spinal cord function after spinal cord injury.

关 键 词：neural regeneration spinal cord injury METHYLPREDNISOLONE NOGO-A OLIGODENDROCYTE spJnal cord pathology myelonecrosis weight-drop contusion photographs-containing paper NEUROREGENERATION 

分 类 号：R651.2[医药卫生—外科学]