CT联合血清CAl25和人附睾蛋白4对卵巢上皮性癌的诊断价值  

The diagnostic value of CT in combination with serum CA125 and HFA for ovarian cancer

作　　者：马赟[1] 肖立志[2] 龚颖萍[1] 崔毅[1] 

机构地区：[1]湖南省妇幼保健院妇科,长沙4l0008 [2]中南大学湘雅二医院PET—CT中心

出　　处：《中国医师杂志》2013年第2期197-199,共3页Journal of Chinese Physician

摘　　要：目的探讨cT联合血清CAl25和人附睾蛋白4（HFA）对卵巢上皮性癌的诊断价值。方法对本院52例卵巢上皮癌（卵巢癌组）、47例卵巢上皮性良性肿瘤（对照组）、40例体检健康妇女（健康组）测定血清CM25、HE4-水平，术前1周内对卵巢癌组和对照组患者行cr检查，分析CT联合血清CAl25和HFA对卵巢上皮性癌的诊断价值。结果卵巢癌组CAl25、HE4水平[（264．374-138．46）KU／L，（280．384-135．14）pmol／L]高于对照组[（52．51±5．29）KU／L，（40．524-10．34）pmol／L]和健康组[（10．694-6．15）KU／L，（37．244-9．84）pmol／L]，其差异均有统计学意义（P〈0．01）。血清CAl25水平对照组与健康组比较差异有统计学意义（P〈0．05）；血清HE4水平对照组高于健康组，但差异无统计学意义（P〉0．05）。CAl25、HE4和cT三种方法在诊断卵巢癌的灵敏度（65．4％，80．8％，75．0％）、特异度（74．5％，85．1％，76．6％）和准确度（69．7％，82．8％，75．8％）比较差异均无统计学意义（P〉0．05）。CT与CAl25、HE4联合诊断能提高卵巢癌的诊断敏感度（92．3％）、特异度（93．6％）及准确度（94．8％），与单项方法比较，差异有统计学意义（〈：7．461，18．711，P〈0．01），与其中两项联合比较，差异无统计学意义（P〉0．05）。结论卵巢上皮性癌患者血清CAl25、HFA水平显著升高，联合卵巢上皮性癌cT影像学改变能提高其诊断的敏感度、特异度、准确度，上述三项联合检查对良恶卵巢上皮性肿瘤具有鉴别诊断意义。Objective To study the diagnostic value of CT combined CA125 and HFA in differentiating the ovarian cancer from the benign. Methods A case-control study included 52 ovarian cancer pa tients, 47 patients with benign ovarian tumors, and 40 healthy control subjects. Preoperative serum levels of HFA and CA125 were measured and CT was performed. Results The serum levels of CA125 and HFA in the ovarian cancer groups [ （264.37 ± 138.46）KU/L, （280. 38 ± 135.14）pmol/L ] were significantly higher than that in the benign ovarian neoplasm group [ （52. 51 ± 5.29）KU/L, （40. 52 ± 10. 34）pmol/L] and healthy control group [ （ 10. 69 ± 6. 15 ） KU/L, （ 37.24 ± 9. 84） pmol/L] （ P 〈 0. 01 ）. The serum levels of CA125 showed statistically significant difference between the benign ovarian neoplasm groups and healthy control groups （ P 〈 0.05 ）. The serum levels of HE4 did not show statistically significant difference between the benign ovarian neoplasm groups and healthy control groups （ P 〉 0. 05 ）. The diagnostic sensitivity （65.4%, 80. 8%, 75. 0% ）, specificity （74. 5%, 85. 1%, 76. 6% ）, and accuracy （69. 7%, 82. 8%, 75. 8% ） of each CA125, HE4, CT method for ovarian cancer did not show statistically significant difference （ P 〉0. 05）. The diagnostic sensitivity （92. 3% ）, specificity （93.6%） and accuracy （94. 8% ） of cornbination of CA125 and HFA and CT were significantly higher and showed statistically significant difference compared with one method （ X2 = 7.461 18. 711, P 〈 0.01 ）, but no significant difference compared with any two methods （ P 〉0. 05）. Conclusions The serum levels of HE4 and CA125 in the ovarian cancer group were significantly higher, and CT in combination with those two serum indices improved the diagnostic sensitivity, specificity, and accuracy of ovarian cancer.

关 键 词：抗原 肿瘤相关 碳水化合物 血液 卵巢肿瘤 诊断 卵巢肿瘤 放射摄影术 体层摄影术 x线计算机 

分 类 号：R737.31[医药卫生—肿瘤]