奥曲肽治疗急性肠梗阻临床疗效分析  

Clinical value of octreotide in treatment of acute bowel obstruction

作　　者：方征[1] 高登辉[1] 王恒毅[1] 

机构地区：[1]安徽医科大学第一附属医院急诊外科,合肥230022

出　　处：《安徽卫生职业技术学院学报》2012年第6期16-17,共2页Journal of Anhui Health Vocational & Technical College

摘　　要：目的:探讨奥曲肽对急性肠梗阻的治疗作用。方法:将急性肠梗阻患者66例随机分为治疗组(32例)和对照组(34例),均常规采用禁食、胃肠减压、灌肠、补液、预防感染、营养支持等治疗方法,其中治疗组加用奥曲肽0.1mg,皮下注射,Q8h,直到梗阻解除,观察两组患者症状体征缓解情况的时间、胃肠减压量、恢复自主排气时间及治疗的有效率。结果:治疗组和对照组症状缓解时间分别为(12.1±3.4)h和(34.3±4.1)h,P<0.01;24h胃肠减压量分别为(357±73)ml和(890±95)ml,P<0.01;恢复自主排气时间分别为(32.5±7.0)h和(58.5±6.2)h,P<0.01;治疗有效率分别为84.4%和67.6%,P>0.05。结论:急性肠梗阻常规治疗中加用奥曲肽可有效缓解患者临床症状,促进肠道功能恢复。Objective ： To study the effect ofotreotide in patients with acutebowel obstruction.Methods ： 66 cases of acute bowel obstruction were selected and devided into two groups.： treatment group （n=32） and control group（n=34）. The patients in control group were treated with fasting, gastrointestinal decompression, clyster, fluid infusion, antibi- otics and total parenteral nutrition.The patient in treatment group received hypodermic injection of octreotide（0.1mg, q8h） plus routine therapy,until obstruction was released. The remission time of symptoms,gastrointestinal secretions, the the anal exhaust time and the efficient rate were observed.Results： The remission time of symptoms was （12.1 ＋ 3.4）hours in treatment group and （34.3 ＋ 4.1 ）hours in the control group（P〈0.01）,.while the gastrointestinal drainage after 24 hours was （357 ＋ 73 ）ml and （890 ~ 95 ）ml respectively. Moreover, the anal exhaust time in octreotide group （32.5 ~ 7.0 h）was shorter than that （58.5 ~ 6.2 h）in the routine group notably （P〈0.01） .However, the efficient rate of the two groups was similar （P〉0.05）,with 84.4 percent and 67.6 percent respectively.Conclusion：The use of octreotide, based on routine treatment ,can effiectively relieve the symptoms of patients suffering from acute bowel obstruction and promote the recovery of bowel functions.

关 键 词：肠梗阻 奥曲肽 疗效 

分 类 号：R574.2[医药卫生—消化系统]