CD105、Ki67在卵巢上皮癌中的表达及其临床意义  

Expression and clinical significance of CD105 and Ki67 in epithelia ovarian cancer

作　　者：刘萍[1] 侯小赛[1] 

机构地区：[1]内蒙古医学院第三附属医院妇产科,内蒙古包头014010

出　　处：《中国现代医学杂志》2012年第33期37-40,共4页China Journal of Modern Medicine

基　　金：内蒙古自治区自然科学基金项目(No:2012MS1134)

摘　　要：目的通过分析CD105和Ki67蛋白在人卵巢上皮癌(EOC)中的表达方式,评估这两个标记物在EOC上的联合表达情况及其临床意义。方法使用免疫组化的方法检测82个卵巢上皮癌患者的石蜡包埋标本中的CD105和Ki67蛋白表达,及CD105和Ki67在卵巢上皮癌不同临床参数中的表达情况,分析卵巢上皮癌病人的CD105和Ki67蛋白联合表达意义。结果 CD105和Ki67蛋白在卵巢上皮癌患者中的阳性表达分别为62/82(75.70%)和59/82(72.45%),CD105是同Ki67正性相关(r=0.91,P=0.00)。结论提示CD105和Ki67蛋白的相互作用可能涉及卵巢上皮癌的发生、发展及患者的预后;使用对CD105、Ki67蛋白的复合表达的联合检测在卵巢上皮癌患者预后的评估中可能有益。[Objective] To analyzing the expression of CD105 and Ki67 in human epithelial ovarian cancer （EOC） assessment and clinical significance of the combined expression of these two markers on the EOC. [Methods] Immunohistochemical S-P method was used to detect the expression of CD105 and Ki67 in paraffin-embedded specimens of 82 cases ovarian cancer, and CD105 and Ki67 expression in different clinical parameters in epithelial ovarian cancer situation, and study the signification of co-expression of CD105 and Ki67 protein in epithelial ovarian cancer. [Results ] CD105 and Ki67 positive expression in epithelial ovarian cancer among were 62/82（75.70%） and 59/82 （72.45%）. CD105 is the same Ki67 positive correlation（r =0.91, P 〈0.05）. [Conclusion] CD105 and Ki67 protein interactions may be involved in the occurrence, development and prognosis of epithelial ovarian cancer; using CD105 expression of Ki67 protein composite joint detection may be useful in the assessment of epithelial ovarian cancer prognosis.

关 键 词：CD105 KI67 卵巢上皮癌 相关性 

分 类 号：R737.31[医药卫生—肿瘤]