单次血清HCG、P检测对体外受精-胚胎移植后妊娠结局的预测价值  

Paired detection of serum human chorionic gonadotropin possibly predicting pregnant outcome after invitro fertilization a large scale retrospective research

作　　者：邵静宜[1] 马艳萍[1] 林娜[1] 

机构地区：[1]云南省第一人民医院生殖遗传一科,云南昆明650032

出　　处：《中国现代医学杂志》2012年第33期102-105,共4页China Journal of Modern Medicine

摘　　要：目的探讨单次血清HCG、P检测在IVF-ET中作为妊娠结果的预测价值。方法回顾性分析435个体外授精-胚胎移植(IVF-ET)周期患者的妊娠结果与ET后第14天的血清HCG、P水平。结果临床妊娠组HCG、P水平均显著高于生化妊娠组(P<0.01)。持续妊娠组HCG、P水平显著高于不良妊娠组(P<0.01)。多胎组HCG水平显著高于单胎组(P<0.01),而P则与单胎组无明显差异(P>0.05)。以HCG≥100 mIU/mL且P≥20 ng/mL作为临床妊娠的预测标准,阳性预期值为99.72%,敏感性为87.93%,特异性为96.55%;以HCG≥500 mIU/mL作为多胎妊娠的预测标准,阳性预期值为66.39%,阴性预期值为76.15%,敏感性为60.90%,特异性为80.19%。结论在IVF-ET周期中ET后第14天血清HCG、P在预测妊娠结果方面具有重要临床价值。[ Objective ] To assess the predictive value of single serum HCG and P determinations in pregnancy outcome after IVF-ET. [Methods] The pregnancy outcomes and the serum HCG and P levels of 14 d after ET in 453 cycles of in vitro fertilization and embryo transfer （IVF-ET） were studied retrospectively. [Results] The serum HCG and P levels of clinical pregnancies were significantly higher than of biochemical pregnancies （P 〈0.01）. The serum HCG and P levels of persistent pregnancies was significantly higher than of abortions and ectopic pregnancies （P 〈0.01）. The serum HCG level of multiple pregnancies was significantly higher than of singleton pregnancies, but the P level was not significantly different between these two groups （P 〉0.05）. To the cutoff value of HCC≥ 100 ml- U/mL and P≥ 20 ng/mL in distinguishing clinical pregnancy, the positive predictive value was 99.72%, the sensi- tivity was 87.93%, the specificity was 96.55%. According to the cutoff value of HCC〉500 mIU/mL in distinguishing multiple pregnancy, the positive predictive value was 66.39%, the negative predictive value was 76.51%, the sensitivity was 60.90%, the specificity was 80.19%. [Conclusion] A single serum HCG and P levels on 14 d after ET provides a useful predictor for pregnancy outcomes in IVF.

关 键 词：人绒毛膜促性腺激素(HCG) 孕酮(P) 体外授精-胚胎移植(IVF-ET) 妊娠 

分 类 号：R394[医药卫生—医学遗传学]