不同剂量阿司匹林肠溶片治疗急性脑梗死的疗效观察  

The Effect Observation of Different Doses of Aspirin Enteric-coated Tablets in the Treatment of Acute Cerebral Infarction

作　　者：岳亚敏[1] 乔柏[1] 

机构地区：[1]鹤壁煤业(集团)有限责任公司总医院,河南省鹤壁市458000

出　　处：《实用心脑肺血管病杂志》2013年第2期7-8,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨不同剂量阿司匹林肠溶片治疗急性脑梗死的临床疗效。方法将87例急性脑梗死患者随机分为两组,A组44例口服100mg阿司匹林,B组43例口服300mg阿司匹林,两组均联合皮下注射5000U低分子肝素治疗。1周为1个疗程,3个疗程末观察两组患者的临床疗效和治疗前后神经功能缺损评分。结果 A组总有效率为72.7%,B组总有效率为93.0%,两组患者疗效比较,差异有统计学意义(P<0.05)。治疗前、治疗第1疗程末两组患者神经功能缺损评分比较,差异无统计学意义(P>0.05);治疗第2疗程末、第3疗程末两组患者神经功能缺损评分比较,差异有统计学意义(P<0.05)。结论口服300mg阿司匹林治疗急性脑梗死的效果明显优于口服100mg阿司匹林,且能明显改善神经功能。Objective To investigate the effects of different doses of aspirin enteric - coated tablets in the treatment of acute cerebral infarction. Methods 87 cases of acute cerebral infarction were randomly divided into two groups, 44 cases in group A 100mg oral aspirin, 43 cases of B group 300mg oral aspirin, two groups were combined with subcutaneous injection of low molecular heparin in treatment of 5000U. In 1 weeks for 1 courses, 3 courses at the end of two groups was observed before and after treatment the clinical curative effect and nervous function defect score. Results In A group, the total effective rate was 72.7%, in B group, the total effective rate was 93.0%, therapeutic effects in the two groups, the difference was statistically significant （P 〈 0. 05）. Before treatment, treatment at the end of the first course in two groups of patients with neurological deficit score comparison, the difference was not statistically significant （P 〉 0. 05） ; treatment at the end of the second course, at the end of the third course in two groups of patients with neurological deficit score comparison, the difference was statistically significant （P 〈 0. 05 ）. Conclusion 300mg oral aspirin study group treatment is superior to the 100mg oral aspirin study group, curative effect is exact, marked neurological improvement.

关 键 词：阿司匹林 肝素 低分子量 脑梗死 治疗结果 

分 类 号：R743.33[医药卫生—神经病学与精神病学]