莫诺苷对局灶性脑缺血再灌注大鼠血液黏度的影响  

Effect of Morroniside on Blood Viscosity in Focal Cerebral Ischemia/Reperfusion in Rats

作　　者：潘红[1,2] 孙芳玲[2] 王晓峰[2] 王文[2] 艾厚喜[2] 张丽[2] 安宜[1] 

机构地区：[1]北京理工大学,北京市100081 [2]首都医科大学宣武医院药物研究室,北京市100053

出　　处：《中国康复理论与实践》2013年第2期107-109,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：科技部"十二五"重大创新药专项(No.2012ZX09102-201-016);国家自然科学基金(No.81173575);国家自然科学基金(No.30740053);北京市自然科学基金(No.7062031);北京市教委科研基地-科技创新平台(No.111219);北京市卫生系统高层次卫生技术人才(No.2011-3-097)

摘　　要：目的研究莫诺苷对大鼠局灶性脑缺血损伤后血液黏度的影响。方法 Longa法制备大鼠局灶性脑缺血模型,造模后,分别给予莫诺苷(30 mg/kg、90 mg/kg、270 mg/kg)连续灌胃7 d,通过全自动血流变仪和微量血浆测试装置检测其全血黏度和血浆黏度。结果与假手术组相比,模型组全血黏度和血浆黏度均显著升高(P<0.001);与模型组相比,莫诺苷各剂量组全血黏度和血浆黏度显著降低(P<0.001)。结论莫诺苷能有效减少大鼠局灶性脑缺血模型引起的血液黏度升高。Objective To explore the effect of morroniside on blood viscosity in focal cerebral ischemia/reperfusion in rats. Methods The animal model was induced with occlusion of middle cerebral artery （MCAO）, and morroniside （30 mg/kg, 90 mg/kg, 270 mg/kg） was then administered intragastrically for 7 d. Whole blood viscosity and plasma viscosity were detected with auto-hemorheological instrument and microplasma testing device. Results Compared with sham-operated group, both whole blood viscosity and plasma viscosity significant- ly increased in ischemic rats （P〈0.001）; however, morroniside reduced whole blood and plasma viscosity noticeably （P〈0.001）. Conclusion Morroniside can inhibit the increase of blood viscosity induced by focal cerebral ischemia/reperfusion in rats.

关 键 词：莫诺苷 缺血 再灌注 血液黏度 血浆黏度 大鼠 

分 类 号：R743[医药卫生—神经病学与精神病学]