Barrett食管病理分型 组织异型性与环氧合酶2及幽门螺杆菌感染的相关性研究  

作　　者：陈小霞 闵春明[2] 赵华 廖文华 宋方敏 

机构地区：[1]湖北省郧西县人民医院消化科,442600 [2]湖北医药学院附属人民医院肛肠外科,442000

出　　处：《浙江临床医学》2013年第3期330-332,共3页Zhejiang Clinical Medical Journal

摘　　要：目的探讨食管腺癌前期（BE）患者食管病理分型、组织异型性与环氧合酶2（COX．2）及幽门螺杆菌（HP）感染的关系。方法采用免疫组化法及14C-尿素呼气试验检测137例BE患者及134例健康者食管中COX-2和HP感染的表达情况。结果COX-2在BE中高表达，而在正常组织中无表达或弱表达，COX-2表达与BE病理类型及组织异型性，差异有统计学意义（P〈0．01）；HP感染率在BE及正常组织中表达差异无统计学意义（P〉0．05），与BE病理类型及组织异型性差异无统计学意义（P〉0．05）。结论BE中COX．2的表达与BE的病理类型及组织异型性有关，提示COX-2表达与BE的发生发展有密切关系，而BE的发生与HP状态无关。Objective To explore the correlations of pathological typing, tissue atypia and COX-2 and helicobacter pylori （HP） infection in the patients of Barrett esophagus（BE）. Methods Immunohistochemisty and 14C-urea breath test were applied to measure the expression of COX-2 and HP infection in 137 patients of BE and 134 healthy people as control. Results The expression of COX-2 was high in BE while low or none in normal tissues, the expression of COX-2 was statistically different among different pathological types, tissue atypia of BE （ P〈0.01 ） , the difference of HP infection rates was not statistically different among different pathological types, tissue atypia of BE （ P〉0.05 ） . Conclusions The expression of COX-2 is statistically correlated to different pathological types, tissue atypia of BE,which implied that the COX-2 has a close relationship to the progression of BE while HP doesn＇t.

关 键 词：BARRETT食管 病理分型 组织异型性 环氧合酶2 幽门螺杆菌 

分 类 号：R571[医药卫生—消化系统]