化疗所致胃肠道反应对乳腺癌患者情绪影响的调查分析  

Analysis of chemotherapy - induced gastrointestinal reactions on the mood status of patients with breast cancer

作　　者：汤大北[1] 张清媛[1] 马文杰[1] 李双[1] 刘凤琴[1] 田洁[1] 陶世鑫[1] 

机构地区：[1]哈尔滨医科大学附属第三医院乳腺综合内科,哈尔滨150081

出　　处：《实用肿瘤学杂志》2013年第1期46-50,共5页Practical Oncology Journal

基　　金：大学生创新能力培养项目（2011-3）;哈尔滨市青年科技创新人才项目（2007RFQXS086）;黑龙江省卫生厅重点项目（2007-390）

摘　　要：目的分析化疗所致胃肠道反应对乳腺癌患者抑郁，焦虑状态的影响。方法对74例化疗后恶心及56例化疗后无恶心的乳腺癌患者采用自编一般情况问卷、Zung抑郁自评量表（sDs）和Zung焦虑自评量表（SAS）评定其抑郁、焦虑状态。恶心组患者症状得到有效控制并结束一周期化疗后，再次对其进行量表调查。结果恶心组及无恶心组存在抑郁症状人数分别为38人和14人，焦虑症状人数分别为29人和11人，两者比较差异具有统计学意义（P〈0．05）；恶心组及无恶心组抑郁评分各为54．64±11．49及42．00±8．92，焦虑评分各为51．29±10．17及41．45±7．94，两者比较差异具有统计学意义（P〈0．05）。患者恶心得到有效控制后，抑郁评分为46．56±9．45，焦虑评分为44．05±8．36，与未控制前比较均明显降低，差异具有统计学意义（P〈0．05），但仍高于无恶心组（P〈0．05）。结论化疗所致胃肠道反应与乳腺癌患者抑郁、焦虑状态的发生和持续有关。Objective To investigate the effect of chemotherapy - induced gastrointestinal reactions on the mood status of patients with breast cancer undergoing chemotherapy. Methods 74 breast cancer patients with chemotherapy - induced nausea and 56 breast cancer patients without chemotherapy - induced nausea were as- sessed with Self - Designed Questionnaire, Self - Rating Depression Scale （SDS） and Self - Rating Anxiety Scale （SAS）. After the nausea control,the SDS and SAS were assessed again. Results The number of depression in breast cancer patients with chemotherapy - induced nausea and without chemotherapy - induced nausea were 38 and 14,respectively（P 〈 0.05 ）. The number of anxiety in breast cancer patients with chemotherapyinduced nausea and without chemotherapy - induced nausea were 29 and 11, respectively （ P 〈 0.05 ）. The scores of SDS in nausea and non - nausea groups were 54.64 ± 11.49 and 42.008.92, respectively. The scores of SAS in nausea and non - nausea groups were 51.29± 10.17 and 4l. 45 ± 7.94, respectively （ P 〈 0.05 ）. The scores of SDS and SAS in nausea group were lower after nausea released ,but it was still higher than non -nausea group（ P 〈 0.05 ）. Conclusion Chemotherapy - induced gastrointestinal reactions have effect on the mood status of patients with breast cancer.

关 键 词：乳腺癌 化疗 恶心 抑郁 焦虑 

分 类 号：R737.9[医药卫生—肿瘤]