TNBC原发灶与腋淋巴结转移灶中ER、PR、Her-2的表达变化与预后的相关性  

A study on the ER, PR and Her -2 expression statuses between primary lesion and metastatic axillary lymph nodes of TNBC

作　　者：周秋锋[1] 岳双磊[2] 吴红梅[1] 齐蕾[1] 杨春[1] 孙文广[1] 王立峰[1] 

机构地区：[1]哈尔滨医科大学附属第一医院哈尔滨,150001 [2]哈尔滨医科大学附属第三医院

出　　处：《实用肿瘤学杂志》2013年第1期54-59,共6页Practical Oncology Journal

基　　金：黑龙江省自然科学基金项目（D201103）

摘　　要：目的探讨雌激素受体、孕激素受体、人表皮生长因子受体-2在三阴性乳腺癌原发灶和腋淋巴结转移灶中表达有无差异及其与患者预后的相关性。方法运用免疫组化法分别检测45例TN—Bc原发灶及腋淋巴结转移灶中ER、PR、Her-2的表达，用Kaplan—Meier生存曲线分析TNBC腋淋巴结转移灶中这些指标的变化与生存时间的关系。结果与TNBC原发灶相比，腋淋巴结转移灶中ER、PR、Her-2仍表达阴性的患者占48．9％，而至少有一项指标表达阳性的患者占51．1％，即与原发灶表达不一致，差异具有统计学意义，且这种表达差异与生存时间存在相关性（P=0．013）。腋淋巴结转移灶免疫组化表达与原发灶一致组的生存时间要短于不一致组（P=0．010），用LogRank法检验具有统计学意义（P=0．048）。结论ER、PR、Her-2在TNBC原发灶和腋淋巴结转移灶中的表达存在不一致现象，且这种不一致现象与生存时间具有相关性。Objective To investigate the difference of expressions of ER, PR and Her 2 status between primary lesion and metastatic axillary lymph nodes of TNBC, and the relationship between the variability and prog nosis of patients. Methods The expressions of ER, PR and Her 2 were detected in primary lesion and metastat ic axillary lymph nodes in 45 cases of TNBC by immunohistochemistry, and then analyzed the relationship between modifications of these markers and live time by Kaplan Meier survival curves. Results Compared with the pri mary lesion of TNBC ,48.9% patients＇axillary lymph node metastases of ER, PR and Her 2 still expressed nega tive, but 51.1% patients had at least one marker positive expression, means immunohistochemical staining of axil lary lymph nodes were different to primary lesion ,with a significant difference between them. The expression varia bility was significant correlated with live time（ P = 0. 013 ）. The live time of the group which immunohistochemical staining of axillary lymph nodes similar to the primary lesion of TNBC was shorter than the group that was differ ent to primary lesion（ P =0.010） ,and there had statistical significance by Log Rank method（ P = 0. 048 ）. Con clusion In primary lesion and metastatic axillary lymph nodes of TNBC,the expressions of ER,PR and Her 2 were difference. And the variability was correlated with life time of patients.

关 键 词：三阴性乳腺癌 淋巴结转移 预后 

分 类 号：R737.9[医药卫生—肿瘤]