利培酮治疗的分裂症患者催乳素与胰岛素敏感性相关性的初步研究  

The association of prolactin and insulin sensitivity in risperidone treatment of patients with schizophrenia

作　　者：寻知元[1] 张国双[1] 江芮[1] 吕浩[1] 

机构地区：[1]天津市安定医院,300222

出　　处：《四川精神卫生》2013年第1期1-5,共5页Sichuan Mental Health

摘　　要：目的初步探讨利培酮治疗的分裂症患者催乳素水平与胰岛素敏感性的相关性。方法对符合入组标准的51例服用利培酮治疗的住院分裂症患者记录年龄、利培酮的使用剂量、分裂症病期等一般情况,测量身高、体重,并检测空腹血糖、血清催乳素及胰岛素(FINS)。计算稳态模型的胰岛素抵抗指数(HOMA-IR)和QUICKI胰岛素敏感性指数。依据体重指数(BMI)将患者分为正常体重组(BMI:18.5～23.9)和超重组(BMI≥24kg/m2),使用Pearson相关分析分析血清催乳素与胰岛素敏感性指标的相关性。结果催乳素与FINS、HOMA-IR、QUICKI胰岛素敏感性指数(r=0.149,P>0.05;r=0.134,P>0.05;r=-0.103,P>0.05)均无统计意义的相关性。正常体重组与超重组的催乳素水平无统计学差异(t=0.597,P>0.05)。超重组FINS、HOMA-IR高于正常体重组(t=2.679,P<0.05;t=2.753,P<0.05),超重组QUICKI胰岛素敏感性指数低于正常体重组(t=3.697,P<0.01)。结论服用利培酮治疗的分裂症患者催乳素水平与胰岛素抵抗无统计意义的相关性。Objective The aim of this study was to explore the correlations between prolaetin and insulin sensitivity in risperidone treatment of patients with schizophrenia. Methods The age, dose of risperidone, duration of schizophrenia, height of 51 inpatients treated with risperidone were recorded. Fast plasma glucose, fast insulin （ FINS）, prolaetin were measured at the same time. Homeostasis model assessment insulin resistance （HOMA - IR）and QUICKI were calculated. The subjects were assigned to two groups based on their body mass index （ BMI ） ： normal - weight group （ BMI ： 18.5 - 23.9 ）, overweight group （ BMI≥ 24kg/ m^2）. The correlations between hyperprolaetinaemia and insulin sensitivity,body fat index and insulin sensitivity were analysed by Pearson correlation analysis. Results Prolactin was not correlated with fast insulin, HOMA - IR, QUICKI （ r = 0. 149, P 〉 0. 05 ; r =0. 134,P 〉0. 05 ;r = -0. 103 ,P 〉0. 05）. There was no significant difference in prolactin level between normal -weight group and overweight group （ t = 0. 597, P 〉 0. 05 ）. FINS and HOMA - IR were higher （ t = 2. 679, P 〈 0. 05 ; t = 2. 753, P 〈 0. 05 ）, and QUICKI were lower in overweight group than that in normal - weight group （ t = 3. 697, P 〈 0. 01 ）. Conclusion Prolaetin is not correlated with insulin resistance in risperidone treatment of patients with schizophrenia.

关 键 词：利培酮 分裂症 催乳素 胰岛素敏感性 胰岛素抵抗 

分 类 号：R749.3[医药卫生—神经病学与精神病学]