杏丁~银杏达莫注射液联合易善复治疗非酒精性脂肪性肝炎疗效观察  

Effect of Ginkgo Leaf Extract and Dipyridamole Injection Associated with Polyene Phosphatidylcholine Injection in the Treatment of Non-alcoholic Steaohepatitis

作　　者：张琴[1] 张文涛[1] 郭卉[1] 

机构地区：[1]天津中医药大学第一附属医院肝胆科,天津市300193

出　　处：《中国全科医学》2013年第5期565-567,共3页Chinese General Practice

摘　　要：目的探讨杏丁银杏达莫注射液联合易善复治疗非酒精性脂肪性肝炎(NASH)的临床疗效,为临床治疗该病提供参考与新思路。方法选择2011年6月—2012年3月在我院住院治疗的NASH患者60例,按随机数字表法分为治疗组和对照组,每组30例。两组患者均进行积极的基础治疗,对照组在此基础上给予易善复注射液15 ml加入5%葡萄糖溶液250 ml,静脉滴注,1次/d;治疗组在对照组基础上给予杏丁银杏达莫注射液25 ml加入0.9%氯化钠溶液250 ml或5%葡萄糖溶液250 ml,静脉滴注,1次/d。两组疗程均为2周。观察并比较两组患者治疗前和治疗后生化指标〔包括丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、三酰甘油(TG)、总胆固醇(TC)〕、血小板聚集率(ADP)及血红蛋白(Hb)水平;同时观察并记录两组患者治疗过程中的不良反应情况。结果治疗前,两组患者ALT、AST、TG、TC水平比较,差异均无统计学意义(P>0.05);治疗后,仅ALT水平间差异有统计学意义(P<0.01)。治疗前,两组患者ADP及Hb水平比较,差异均无统计学意义(P>0.05);治疗后比较,差异均有统计学意义(P<0.01)。对照组未见与治疗相关的不良反应;治疗组2例患者在治疗初期出现头胀痛。结论杏丁银杏达莫注射液联合易善复治疗NASH的临床疗效好,安全可靠,值得推广应用。Objective To observe the treatment effect of ginkgo leaf extract and dipyridamole injection associated with polyene phosphatidylcholine injection in the treatment of non - alcoholic steaohepatitis （NASH）. Methods 60 NASH patients hospitalized from June 2011 to March 2012 were randomly divided into treatment group and control group with each group 30 ca- ses. The two groups were both given basic treatments. The control group was also given intravenous drip of 15 ml polyene phos- phatidylcholine injection in 250 ml 5% glucose solution one time daily, while the treatment group was given additional intrave- nous drip of 25 ml ginkgo leaf extract and dipyridamole injection in 0. 9% sodium chloride solution or 5% glucose solution one time daily. The treatment course of the two groups was two weeks. Biochemical indexes （ALT, AST, TG and TC）, ADP and Hb of the two groups before treatment and after treatment were compared, and the adverse effects of the two groups were also ob- served and recorded. Results Before treatment, the AST, TG, TC, ADP and Hb between the two groups showed no statisti- cally significant differences （P 〉 0. 05 ）. After treatment, ALT, ADP and Hb showed statistically significant differences （ P 〈 0.01 ）. No adverse effect was found in the control group, but two cases had headache at the beginning of treatment in the treat- ment group. Conclusion The effect of ginkgo leaf extract and dipyridamole injection associated with polyene phosphatidylcholine injection in the treatment of non- alcoholic steaohepatitis is good with satisfactory safety and reliability, so it should be recom- mended in clinic.

关 键 词：银杏达莫注射液 脂肪肝 治疗结果 

分 类 号：R575.1[医药卫生—消化系统]