艾司西酞普兰与西酞普兰改善癫痫发作患者抑郁症状的对照研究  

A comparative study of escitalopram vs.citalopram in improving depressive symptoms of patients with epilepsy

作　　者：刘晓静 张艳[2] 李翠鸾[2] 王旸[3] 

机构地区：[1]山东省青岛市经济开发区第一人民医院,266555 [2]山东省精神卫生中心 [3]山东大学医学院精神卫生研究所

出　　处：《精神医学杂志》2013年第1期22-24,共3页Journal of Psychiatry

摘　　要：目的探讨艾司西酞普兰与西酞普兰改善癫痫发作患者抑郁症状的效果。方法将158例伴发抑郁症状的癫痫发作患者随机分为研究组(80例)和对照组(78例),研究组给予艾司西酞普兰系统治疗,对照组给予西酞普兰系统治疗,疗程均为4周。入组患者应用汉密尔顿抑郁量表(HAMD)与不良反应量表(TESS)在基线及治疗后第1、2、4周末分别评定疗效与不良反应。结果与基线相比,研究组HAMD评分在第1周末即有显著性降低(P<0.05),而对照组HAMD评分在第2周末才有显著性降低(P<0.05)。在治疗后的第1、2、4周末,研究组HAMD评分均低于对照组(P<0.05)。在治疗后的第4周末,研究组临床整体疗效优于对照组(P<0.05)。两组均未出现严重不良反应。结论艾司西酞普兰和西酞普兰均可有效、安全地改善癫痫发作患者的抑郁症状,而艾司西酞普兰起效更快,疗效更好。Objective To explore efficacy of escitalopram vs. citalopram in improving depressive symptoms of patients with epilepsy. Methods A total of 158 epilepsy patients with depressive symptoms were randomly divided into study group （80 cases） and control group （78 cases） treated with escitalopram and citalopram respectively for 4 weeks. The efficacy and side effects were assessed with Hamilton Rating Scale for Depression （HAMD） and Treatment Emergent Symptom Scale （TESS） at baseline and the end of the 1 st, 2nd and 4th week of treatment. Results Compared with the baseline, the total scores of HAMD in study group decreased significantly at the 1 st weekend （ P 〈 0.05 ） , while the significance appeared till the 2nd weekend in control group （ P 〈 0.05 ）. The scores of HAMD in study group were significantly lower than those in control group at the 1 st, 2nd and 4th weekend of treatment （ P 〈 0.05 ）. The global efficacy in study group was better than that in control group at the end of the treatment （P 〈 0.05 ）. No severe side effects happened in both groups and there was no significant difference in side effects between the two groups （P 〈 0.05）. Conclusion Both escitalopram and citalopram are effective and safe in improving depressive symptoms of patients with epilepsy. Escitalopram takes effect faster and has better efficacy than eitalopram.

关 键 词：艾司西酞普兰 西酞普兰 癫痫 抑郁症状 

分 类 号：R749.4[医药卫生—神经病学与精神病学]