持久性有机污染物(POPs)生殖毒理研究进展——从实验动物生殖毒性到人类生殖健康风险  

Health implications of POPs on mammal and human reproduction

作　　者：周京花[1] 马慧慧[1] 赵美蓉[2] 刘璟[1] 

机构地区：[1]浙江大学环境与资源学院,杭州310058 [2]浙江工业大学生物与环境工程学院,杭州310032

出　　处：《中国科学：化学》2013年第3期315-325,共11页SCIENTIA SINICA Chimica

基　　金：国家重点基础研究发展计划(2009CB421603);国家自然科学基金(21007056;21077094)资助

摘　　要：与常规污染物不同,持久性有机污染物(Persistent Organic Pollutants,POPs)在环境中滞留时间长,极难降解,毒性强,可在食物链中富集放大,能通过各种环境介质进行全球性迁移,对人类健康带来巨大危害.POPs对健康的影响是多方面的、复杂的,不仅具有"三致"效应(致癌、致畸、致突变性),而且有内分泌干扰作用,对生殖系统、免疫系统、神经系统等产生毒性.生殖健康不仅关乎人类繁衍,更能对人口素质乃至社会的发展产生深远影响,因此,POPs的生殖毒性以及对人类生殖健康的影响一直备受关注.本文在回顾我国POPs环境污染与人类暴露的研究基础上,结合近年来国内外的研究情况,着重讨论几类典型POPs的生殖毒性和致毒机制以及对人类生殖健康的影响,并对存在的问题和今后的关注点进行总结.Persistent organic pollutants （POPs） are organic compounds that are resistant to environmental degradation. POPs have been observed to persist in the environment, to be capable of long-range transport, bioaccumulate in human and animal tissue, biomagnify in food chains, and to have potential significant impacts on human health and the environment. Although some POPs have been banned or restricted to use, they still ubiquitously exist in the environment because of their long half-life. POPs are toxic to human and animals, and some compounds have been identified as carcinogenic, mutagenic, and teratogenic. POPs are also considered as endocrine disruptors, which interfere with the hormone system and can cause birth defects, reproductive and developmental disorders, as well as some cancerous tumors. There is ongoing concern over the risks to human and wildlife reproductive health of POPs. This review introduces the effects of POPs （organochlorine pesticides, dioxins, polychlorinated biphenyls, polycyclic aromatic hydrocarbons and polybrominated diphenyl ethers） on mammal and human reproduction.

关 键 词：POPS 生殖毒理 人类生殖健康 

分 类 号：X171.5[环境科学与工程—环境科学]