埃索美拉唑镁肠溶片预防脑卒中并发胃食管反流病疗效研究  

Clinical Effects of Esomeprazole for Preventing Stroke Complicating Gastroesophageal Reflux Disease

作　　者：张莉[1] 代小松[1] 

机构地区：[1]四川省医学科学院四川省人民医院干部科,成都610072

出　　处：《中国医药导刊》2013年第1期105-106,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:观察埃索美拉唑预防脑卒中并发胃食管反流病的疗效和安全性。方法:选择80例脑卒中患者随机均分为治疗组和对照组。治疗组选用埃索美拉唑治疗;对照组选用法莫替丁治疗,疗程均为2周。比较两组防止脑卒中并发胃食管反流病及伴随症状的情况。结果:治疗组有4例出现了胃食管反流,发生率为10.0%,对照组有11例出现了胃食管反流,发生率27.5%,差异有显著性(P<0.05)。药物不良反应发生率差异无显著性(P>0.05)。结论:埃索美拉唑镁肠溶片为一种预防脑卒中并发胃食管反流病安全、有效的药物。Objective：To observe the clinical effect and safety of Esomeprazole for Preventing Stroke Complicating Gastroesophageal reflux disease.Methods：Eighty patients were randomly enrolled in the trial therapy group and the control group with 40 cases respectively.Esomeprazole and Famotidine were respectively given for two weeks in the therapy group and the control group.The frequency of Stroke Complicating Gastroesophageal reflux disease and adverse reaction were observed.Results：The incidences of Stroke Compli-cating Gastroesophageal reflux disease were 10.0%,27.5% in two groups respectively.There was significant difference between the two groups（P 0.05）.The incidences of adverse reaction were 5.0%,7.5% in two groups respectively.There was no significant difference（P0.05）.Conclusion：Esomeprazole is a safe and effective drug for Preventing Stroke Complicating Gastroesophageal reflux disease.

关 键 词：埃索美拉唑镁肠溶片 法莫替丁 脑卒中 胃食管反流病 

分 类 号：R571[医药卫生—消化系统]