神经干细胞治疗缺血缺氧性脑瘫的现状  

The Current Situation of Treating Hypoxic-ischemic Cerebral Palsy by Neural Stem Cells

作　　者：冯冠军[1] 陈刚[2] 杨小朋[3] 

机构地区：[1]石河子大学医学院,新疆石河子832002 [2]无锡市第四人民医院神经外科,江苏无锡214000 [3]新疆维吾尔自治区人民医院神经外科,乌鲁木齐830000

出　　处：《医学综述》2013年第4期584-587,共4页Medical Recapitulate

基　　金：国家自然科学基金(30960393)

摘　　要：脑性瘫痪又称脑瘫,是指从胚胎形成到出生后1个月内各种原因引起的非进行性脑损伤所导致的综合征,主要表现为运动障碍及姿势异常。其发病机制不明,目前尚无特效治疗方法,特别是对已经完全损伤的神经细胞治疗效果较差。细胞移植和基因治疗技术的飞速发展为治疗此类疾病带来了希望。该文回顾性分析小儿脑瘫的发病机制和近年来国内外关于神经干细胞移植在动物实验及临床中的有效应用、转基因神经干细胞移植治疗,以及干细胞移植所带来的问题等。Cerebral palsy refers to a syndrome of non-progressive brain damage caused by various reasons from embryogenesis to one month after birth of children, with the main manifestations of movement disorders and abnormal posture. Its pathogenesis is unknown,and there is no effective treatment so far,particularly for the nerve cells completely damaged. The rapid development of cell transplantation and gene therapy brings hope for the treatment of such diseases. Here is to make a review on the mechanism of cerebral palsy in chil- dren, recent domestic and international studies of the effective application of neural stem cell transplantation in animal experiments and clinical practice,genetically modified neural stem cell transplantation treatment, and the problems brought along.

关 键 词：脑瘫 神经干细胞 移植 

分 类 号：R742.3[医药卫生—神经病学与精神病学]