脑梗死患者危险因素对生存质量影响的临床评价  

Clinical evaluation on effect of patients' risk factors of cerebral infarction on quality of life

作　　者：王泽祥[1] 刘诗翔[1] 孔繁一[1] 

机构地区：[1]成都军区昆明总医院神经内科,昆明650032

出　　处：《西南国防医药》2013年第3期252-254,共3页Medical Journal of National Defending Forces in Southwest China

基　　金：云南省自然基金面上项目(2010zc185)

摘　　要：目的探讨降纤治疗对脑梗死生存质量的影响。方法回顾2005年1月～2011年11月在本院蛇毒诊疗中心住院治疗的脑梗死患者的病例资料,记录患者的基线资料,随访患者二级预防措施,并对患者进行mRS评分;以mRS评分二分类变量为因变量,各因素为应变量,行Logistic回归分析。结果共收集588例,其中504例通过随访,随访率达到85.7%;Logistic回归分析显示,性别、入院NIHSS评分、降纤治疗、纤维蛋白原、二级预防降血脂纳入模型之中,其中入院NIHSS评分(OR=1.302,95%CI 1.200～1.412)、纤维蛋白原含量(OR=1.455,95%CI 1.143～1.852);性别(OR=0.538,95%CI 0.291～0.996)、降纤治疗(OR=0.187,95%CI 0.093～0.374)、二级预防降脂治疗(OR=0.533,95%CI 0.287～0.991)为脑梗死患者的生存质量的影响因素。结论入院NIHSS评分越高,残疾风险越高;纤维蛋白原含量越高,患者残疾风险越高;未行降纤治疗的患者要比行降纤治疗的患者残疾风险高;未进行二级预防降脂治疗的患者残疾风险偏高。Objective To discuss the effect of defibrase treatment on the quality of life in patients with cerebral infarction. Methods A retrospectively analysis was made in the data of patients with cerebral infarction who were hospitalized in the snake venom treatment center of our Hospital from January 2005 to November 2011. Their baseline data were recorded. Follow - up was made for the patients secondary prevention measures, and mRS scoring was carried out. Using the two categorical variables of the mRS scores as the induced variable factors and other factors as the dependent variable,Logistic regression analysis was carried out. Results Totally 588 cases were collected, and 504 ones （85.7%） of them got through the follow - up. The Logistic regression analysis indicted that gender, admission NIHSS score, defibrase treatment, fibrinogen, and secondary prevention of lowering blood pressure were included in the model. The parameters were as follows： the admission NIHSS score （OR = 1. 302, 95% CI 1. 200 - 1. 412）, the fibrinogen concentration, （ OR = 1. 455,95 % CI 1. 143 - 1. 852） the gender group （ OR = 0. 538,95% CI 0. 291 - 0. 996）, the defibrase treatment group（ OR = 0. 187,95% CI 0. 093 - 0. 374 ） , the secondary prevention of lipid - lowering therapy （ OR = 0. 533,95 % CI O. 287 - 0.991 ）. Conclusion The higher the admission HHSS score, the higher the risk of disability; the higher the content of fibrinogen, the higher the risk of disability in patients. The risk is higher in patients not receiving the defibrase treatment than that in those receiving the treatment. Patients not receiving the secondary prevention lipid - lowering treatment have a higher risk of disability.

关 键 词：脑梗死 危险因素 生存质量 临床评价 

分 类 号：R743.33[医药卫生—神经病学与精神病学]