拉莫三嗪与卡马西平治疗三叉神经痛的疗效对比  

Comparison of curative effect between lamotrigine and carbamazepine on trigeminal neuralgia

作　　者：王迪[1] 边颖[1] 李嫕婧[2] 才晓慧[1] 

机构地区：[1]南方医科大学珠江医院口腔科,广州510282 [2]暨南大学

出　　处：《西南国防医药》2013年第3期270-272,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的观察比较拉莫三嗪与卡马西平治疗原发性三叉神经痛的疗效。方法对30例原发性三叉神经痛患者采取拉莫三嗪单药治疗,30例采取卡马西平单药治疗,以视觉模拟评分法(VAS)比较两组治疗后1个月和2个月的疼痛程度、总有效率及完全缓解率。结果拉莫三嗪组治疗前与治疗结束后VAS比较有明显差异(P<0.01),治疗结束后与卡马西平组组间比较中无明显差异(P>0.05);卡马西平组总有效率优于拉莫三嗪组(P<0.05),但拉莫三嗪组在有效病例中的完全缓解率优于卡马西平组(P<0.05)。结论拉莫三嗪是一种治疗三叉神经痛有效的药物。Objective To observe and make comparison of curative effects between lamotrigine and carbamazepine on trigeminal neuralgia. Methods Thirty patients with primary trigeminal neuralgia received the treatment with lamotrigine, and another 30 ones received the treatment with carbamazepine. According to the visual analogue scales （VAS）, comparison was made in the degree of pain, total effective rate, and complete remission 1 month and 2 months after the treatment between the two groups. Results There were significant differences in the VAS of the lamotrigine group before and after the treatment （P 〈 0.01 ）. After the treatment, there was no significant difference in the VAS among the patients in the carbamazepine group （ P 〉 0.05 ）. The total effective rate of the carbamazepine group was superior to that of the lamotrigine group （ P 〈 0.05 ）, but the complete remission of the effective cases in the lamotrigine group was superior to that in the carbamazepine group. Conclusion Lamotrigine is an effective drug in the treatment of trigeminal neuralgia.

关 键 词：三叉神经痛 拉莫三嗪 卡马西平 疗效 

分 类 号：R745.11[医药卫生—神经病学与精神病学]