P21WAF1、PCNA基因在脑膜瘤中的表达及其意义  

Expression and significance of gene P21WAF1 and PCNA in meningioma tissue

作　　者：熊东胜 李元朋[1] 高强[1] 

机构地区：[1]陕西省宝鸡市人民医院,721000

出　　处：《齐齐哈尔医学院学报》2013年第2期183-184,共2页Journal of Qiqihar Medical University

摘　　要：目的探讨P21WAF1、PCNA基因在脑膜瘤组织中的表达情况与脑膜瘤病理特征的关系及在预后判定方面的意义。方法采用免疫组化染色对40例脑膜瘤和10例正常蛛网膜进行P21WAF1、PCNA检测。结果脑膜瘤组织P21WAF1、PCNA基因表达阳性率分别为;在正常蛛网膜的阳性率分别为90%、20%;P21WAF1和PCNA的阳性率在脑膜瘤组织与正常大肠粘比较有显著性差异(P<0.05)。临床病理联系:PCNA的表达与脑膜瘤的周围浸润有关(P<0.05)。P21WAF1的表达与脑膜瘤的分化程度、淋巴结转移有关。结论 (1)P21WAF1表达下降或缺失可能加速细胞周期转化,促进脑膜瘤的发生及发展。(2)P21WAF1表达下降或缺乏提示为脑膜瘤预后不良的危险因素。(3)二者联合检测有助了解病变的发展阶段和预后评估。Objective ;Fo explore PCNA P21WAF1 in meningioma tissue of the gene expression and meningioma pathological characteristics of the relationship and the meaning of the respect in prognosis judgment. Methods Immunohistochemical staining was performed in 40 patients with meningioma and 10 cases of normal arachnoid to P21WAF1 PCNA detection. Results Meningioma tissue P21WAF1 PCNA positive gene expression respectively; In normal arachnoid positive rate were 90% 20%; P21WAF1 and PCNA positive rate of in meningioma tissue and normal colon stick had more significant difference （ P 〈 0. 05 ）. Clinical pathological relationship ： the expression of PCNA and meningioma around the invasion （ P 〈 0. 05 ）. The expression of P21WAF1 was related to meningioma and the differentiation of lymph node metastasis. Conclusions ①Decrease or absence of the expression of P21WAF1 is likely to accelerate cell cycle transformation and promote the occurrence and development of meningioma. ② Decrease or absence of the expression of P21WAF1 hints the the risk factors of poor prognosis of meniugioma.③ The combined detection of both will help to understand the development stage of the disease and prognosis.

关 键 词：P21WAF1 PCNA 细胞周期 脑膜瘤 免疫组化 

分 类 号：R735.7[医药卫生—肿瘤]