广州地区原发性肺癌危险因素的病例对照研究  

A case-control study for the risk factors of primary lung cancer in Guangzhou

作　　者：赵红军[1,2] 胡建明[1,3] 黎银燕[1] 杨磊[1] 凌晓璇[1] 王云南[4] 曾婉明[5] 曾波航[6] 吕嘉春[1] 

机构地区：[1]广州医学院化学致癌研究所分子流行病学研究室,呼吸疾病国家重点实验室,广东广州510182 [2]甘肃省疾病预防控制中心社区卫生与慢性非传染性病症防治科,甘肃兰州730000 [3]兰州大学第一附属医院呼吸科,甘肃兰州730000 [4]广州市胸科医院内科,广东广州510360 [5]广州医学院附属肿瘤医院内科,广东广州510360 [6]广州医学院第二附属医院肿瘤科,广东广州510260

出　　处：《中华疾病控制杂志》2013年第2期103-105,共3页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(30671813;30671746;30872178;30872142);广东省自然科学基金(07003055;07003060;8251018201000005);广东省高层次人才项目(201079)

摘　　要：目的探讨人群中肺癌的危险因素,为其病因学研究提供线索。方法收集广州地区2007年1月～2009年3月新诊断的原发性肺癌病例808例,选取性别、年龄配对的正常对照808例,通过问卷调查收集病例和对照有关危险因素的暴露史,分析其与肺癌的关系。结果分析发现,吸烟、累计吸烟量>30包/年、被动吸烟来源于父母、肺结核病史、慢性阻塞性肺疾病病史、肿瘤家族史、医源性X线暴露和有金属毒物职业暴露(镍/镉/铬)等可能为肺癌的危险因素(均有P<0.05),而食蔬菜水果≥4次/周为保护因素OR(95%CI):0.31(0.24～0.40)。结论肺癌的发生与多种环境因素有关,从病因学来看,肺癌是可以预防和控制的。Objective To investigate the risk factors of human lung cancers in Guangzhou, and to provide information for the aetiological research. Methods 808 newly diagnosed primary lung cancer cases according to the pathologic diagnoses and equal number of sex-age frequency matched controls were recruited and interviewed in Guangzhou during January 2007 to March 2009. Results With Logistic regression models, eight factors were discovered as the main risk factors of lung cancer, smoking history, amount of smoking, exposure to environmental tobacco smoke from parents, pulmonary tuberculosis, chronic obstructive pulmonary disease, family history of cancer, occupational exposure to metal poisons, iatrogenic X-ray exposure （ all P 〈 0. 05 ）. And often taking fresh vegetables and fruits was found to be a protective factor OR （95% CI） ：0. 31 （0. 24-0. 40）. Conclusions Human lung cancer may be associated with the environmental factors, and it is a preventable disease from its aetiology.

关 键 词：肺肿瘤 病例对照研究 危险因素 

分 类 号：R734.2[医药卫生—肿瘤]