食管贲门癌患者血清CA125表达水平及其临床意义  

Clinical significance of serum levels of CA125 in esophageal and cardiac cancer patients

作　　者：刘联[1] 邹雄[1] 赵健[1] 王善政[1] 

机构地区：[1]山东医科大学附属医院肿瘤中心,济南市250012

出　　处：《肿瘤防治杂志》2000年第1期7-9,共3页China Journal of Cancer Prevention and Treatment

摘　　要：目的 :分析CA12 5与食管贲门癌的关系及临床应用价值。方法 :应用酶联免疫吸附分析法(ELISA法 )测定 10 5例食管贲门癌患者和 73例健康成人血清CA12 5水平。结果 :①食管贲门癌患者的血清CA12 5水平显著高于健康成年人 (P <0 .0 0 1) ;②食管癌患者血清CA12 5水平在肿瘤不同分段间或大体病理类型间差异无显著性 ;③食管贲门癌患者的血清CA12 5水平与肿瘤大小、浸润深度、临床病理分期均呈正相关 ,而与鳞癌分化程度、有无转移无关 ,接受根治术患者的血清CA12 5水平显著低于接受剖胸探查术者 ,CA12 5阴性食管癌患者的肿瘤切除率 ( 94 6% )显著高于阳性患者 ( 70 6% ,P <0 0 2 )。结论 :血清CA12 5水平与食管贲门癌的生长浸润等生物学行为密切相关 ,较高的CA12 5水平提示肿瘤较大、浸润较深及分期较晚 ,且肿瘤可切除性明显降低 。Objective:To study the relationship between serum level of tumor marker CA125 and the clinical course of esophagealcardiac cancer(ECC). Mothods:Serum levels of CA125 were measured by ELISA method. Results:The mean serum level of CA125 in ECC patients (438±201 U/ml) was markedly higher than that of healthy adults (104±147U/ml)(P<0001) with the positive rate 457%, and specificity 932%.The serum level of CA125 in ECC patients had no relationship with the tumor location and gross pathologic type (P>005,P>0.05).Serum CA125 level in ECC patients had a direct relation with tumor size, invasive depth and clinical staging (P<002,P<001,P<05, respectively), but no relationship with tumor differentiation or metastasis (P>005 for all) The mean serum level in patients accepted radical operations was markedly lower (P<001) than the cases with exploratory thoracotomy, meanwhile, the resective rate of tumor in CA125negative patients with esophageal cancer was 946%, markedly higher (P<002) than the CA125positive ones (70.6%). Conclusions:Serum level of CA125 has a certain relationship with some of the biological behaviors of ECC cells such as their activity of growth and invasion, and a higher serum CA125 level tends to indicate a larger tumor, a deeper invasion, an advanced staging or a lower resectability, which has significant clinical value to decide tumor course, choose appropriate treatment modalities, predict resectability and prognosis and so on.

关 键 词：食管肿瘤 贲门肿瘤 CA125 临床意义 

分 类 号：R735[医药卫生—肿瘤]