中国4个民族群体HLA-G基因14bp插入/缺失多态的分布特征及其HLA-A位点的相关性  

Distribution of HLA-G 14 bp insertion/deletion polymorphism and their associations with HLA-A alleles in four Chinese ethnic groups

作　　者：张华[1] 陶玉芬[1] 史磊[1] 姚宇峰[1] 向昊[1] 林克勤[1] 黄小琴[1] 褚嘉祐[1] 史荔[1] 

机构地区：[1]中国医学科学院&北京协和医学院医学生物学研究所,昆明650118

出　　处：《遗传》2013年第2期161-167,共7页Hereditas（Beijing)

基　　金：云南省应用基础研究重点项目(编号:2008CC021);国家自然科学基金项目(编号:30900798)资助

摘　　要：近年来,位于HLA-G基因第8外显子3′UTR的一个14 bp插入/缺失多态位点与复发性流产、自身免疫性疾病和肝癌等疾病相关而引起广泛关注。本实验室前期的研究表明,不同群体的HLA-G基因14 bp插入/缺失频率具有群体语系分布特点。文章对土族、裕固族、傈僳族和怒族进行HLA-G基因14 bp插入/缺失的基因分型,结合HLA-A基因分型数据,分析土族、裕固族、傈僳族和怒族4个民族群体中14 bp插入/缺失与HLA-A等位基因的关系。研究结果显示:(1)尽管HLA-G基因14 bp插入频率在不同群体中的分布具有各自群体的特点,但遵循着按语系及语族分布的规律,除汉藏语系汉语族与阿尔泰语系蒙古语族无差异外,语族间差异明显;(2)不同群体中,14 bp插入与不同的HLA-A等位基因相关联。Recently, a 14 bp insertion/deletion polymorphism （＋14 bp/-14 bp） in exon 8 of the human leucocyte antigen-G （HLA-G） gene has been widely recognized to associate with recurrent miscarriage, autoimmune diseases, hepatocellular carcinoma and other diseases. Our previous studies have shown the distribution characteristics of linguistic family for HLA-G 14 bp insertion/deletion in different ethnic groups. In the present study, we investigated the distribution of HLA-G 14 bp insertion/deletion polymorphism and their subsequent associations with HLA-A alleles in Tu, Yugu, Lisu and Nu ethnic populations based upon the HLA-A genotyping data. Our results showed that the frequencies of the 14 bp inser- tion/deletion polymorphism were diverse in these four populations while that in the same linguistic subfamily was similar. The significant difference in different linguistic subfamily except for Han and Mongolian language subfamily was identified.In addition, the 14 bp insertion was found to associate with HLA-A alleles in different ethnic populations.

关 键 词：HLA-G基因 14bp插入 缺失多态 少数民族群体 语系 HLA-A基因 

分 类 号：R346[医药卫生—基础医学]