A Concise Total Synthesis of Amphidinin B  

作　　者：Dongdong Wu Jinlong Wu Wei-min Dai 

机构地区：[1]Laboratory of Asymmetric Catalysis and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou Zhejiang 310027, China [2]Laboratory of Advaneed Catalysis and Synthesis, Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China

出　　处：《Chinese Journal of Chemistry》2013年第1期105-110,共6页中国化学（英文版）

摘　　要：A concise total synthesis of amphidinin B, a cytotoxic linear dicarboxylic acid associated with amphidinolide T marine macrolides, has been accomplished from the 19-membered cycloalkene intermediates designed for diverted total synthesis of amphidinolide T1 and T3-T5. The lH and 13C NMR spectra of the synthesized amphidinin B in C6D6 and CDC13 were compared with those for the natural and synthetic forms reported in the literature, showing solvent-dependence of the ^1H and ^13C NMR signals of amphidinin B in C6D6 and CDC13.A concise total synthesis of amphidinin B, a cytotoxic linear dicarboxylic acid associated with amphidinolide T marine macrolides, has been accomplished from the 19-membered cycloalkene intermediates designed for diverted total synthesis of amphidinolide T1 and T3-T5. The lH and 13C NMR spectra of the synthesized amphidinin B in C6D6 and CDC13 were compared with those for the natural and synthetic forms reported in the literature, showing solvent-dependence of the ^1H and ^13C NMR signals of amphidinin B in C6D6 and CDC13.

关 键 词：amphidinin B CYCLOALKENE DIHYDROXYLATION oxidative cleavage total synthesis 

分 类 号：TQ465.5[化学工程—制药化工] V31[航空宇航科学与技术—航空宇航推进理论与工程]