A Pd(Ⅱ)-Catalyzed Oxidative Cyclization for the Preparation of AryI-Fused Six-Membered Nitrogen Heterocycles with 2-Acetoxy Functionality  

A Pd（ll）-Catalyzed Oxidative Cyclization for the Preparation of AryI-Fused Six-Membered Nitrogen Heterocycles with 2-Acetoxy Functionality

作　　者：Xiaolei Wang Zhengxing Wu Xiaowen Zhu Chenghao Ye Feng Jiang Wanbin Zhang 

机构地区：[1]School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China [2]State Key Laboratory Base of Novel Functional Materials and Preparation Science, Faculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang 315211, China

出　　处：《Chinese Journal of Chemistry》2013年第1期132-138,共7页中国化学（英文版）

基　　金：Acknowledgement This work was partly supported by the National Natural Science Foundation of China （Nos. 20972095, 21172143, 21232004）, Nippon Chemical Industrial Co., Ltd., the Nature Science Foundation of Ningbo （No. 2012A610086） and Shanghai Jiao Tong University. We thank Prof. Tsuneo Imamoto and Dr. Masashi Sugiya for helpful discussions and the Instrumental Analysis Center of Shanghai Jiao Tong University for HRMS determination.

摘　　要：A Pd（II）-catalyzed oxidative cyclization of olefinic tosylamides was developed for the preparation of aryl-fused and N-containing six-membered heterocycles. Under optimized conditions the reaction proceeded with high activity and selectivity, with yields of up to 83% being obtained. This procedure provides a facile and efficient route to the aforementioned heterocycles with 2-acetoxy functionality.A Pd（II）-catalyzed oxidative cyclization of olefinic tosylamides was developed for the preparation of aryl-fused and N-containing six-membered heterocycles. Under optimized conditions the reaction proceeded with high activity and selectivity, with yields of up to 83% being obtained. This procedure provides a facile and efficient route to the aforementioned heterocycles with 2-acetoxy functionality.

关 键 词：PALLADIUM oxidative cyclization six-membered ring nitrogen heterocycle 2-acetoxy functionality 

分 类 号：TQ450.6[化学工程—农药化工] X172[环境科学与工程—环境科学]