Dynamin-related protein 1在线粒体分裂和细胞凋亡中的作用  

The Function of Dynamin-Related Protein 1 in Mitochondrial Fission and Apoptosis

作　　者：张歌[1] 朱帆[1] 单寅鑫 聂唯天[1] 宫健 单春华[1] 

机构地区：[1]东北林业大学生命科学学院,哈尔滨150040 [2]黑龙江科技职业学院,哈尔滨150111

出　　处：《生物物理学报》2013年第2期87-93,共7页Acta Biophysica Sinica

基　　金：东北林业大学研究生科技创新项目(STIP10);东北林业大学国家基础科学人才培养基金(J1210053)~~

摘　　要：Dynamin-related protein 1属于动力蛋白GTP酶超家族,是线粒体分裂体系的组成成分,在线粒体分裂中具有重要作用。在不同物种中,dynamin-related protein 1在与多种分子相互作用后,可以定位于线粒体并组装成高级结构,引起膜的收缩和分裂。Dynamin-related protein 1功能的消失会增强线粒体的融合和线粒体之间的连通性。Dynamin-related protein 1在细胞凋亡等多种细胞功能中也具有重要作用。Dynamin-related protein 1 belongs to the dynamin GTPase superfamily. As the composition of mitochondrial fission system, Dynamin-related protein 1 plays an important role in mitochondrial fission. After interacting with a variety of molecules, Dynamin-related protein 1 can be located in mitochondria and assembled into higher structure, causing the contraction and fission of membranes in different species. The function loss of Dynamin-related protein 1 enhances mitochondrial fusion and connectivity. Dynamin-related protein 1 is also related to many kinds of cell functions such as apoptosis.

关 键 词：Dynamin-related PROTEIN 1 线粒体分裂 细胞凋亡 

分 类 号：Q2[生物学—细胞生物学] Q51