超声辅助合成非洛地平的研究  

Synthesis of felodipine under ultrasonic irradiation

作　　者：何敬宇[1] 胡瑞省[1] 刘斯婕[1] 贾会珍[1] 田竞超[1] 王晓霞[1] 师维康[1] 高翔[1] 杨凯[1] 安文墨[1] 

机构地区：[1]石家庄学院化工学院,河北石家庄050035

出　　处：《精细与专用化学品》2013年第3期16-17,20,共3页Fine and Specialty Chemicals

基　　金：石家庄学院博士科研启动基金和石家庄科学技术研究与发展计划项目(12120453)

摘　　要：以2,3-二氯苯甲醛、乙酰乙酸乙酯和3-氨基巴豆酸甲酯为起始原料,在无溶剂条件下,采用超声辅助的方式合成了非洛地平,产品收率可达83.6%。对产品进行了MP,IR,1HNMR和MS检测。该合成工艺具有环保、反应时间短、操作简便和产率高等优点。Felodipine was obtained by using 2,3-dichlorobenzaldehyde, ethyl acetoaeetate and 3-amino methyl crotonate as starting materials under ultrasonic irradiation condition without solvent. The yield was 83.6%. The product was confirmed by MP, IR, 1 HNMR and MS. The advantages of the process were enviromental protection, short reaction time, easy operation and high yield.

关 键 词：非洛地平 超声波 合成 

分 类 号：R914[医药卫生—药物化学]