大鼠部分坐骨神经损伤模型中机械痛敏和冷痛敏的性别差异  

SEX DIFFERENCES IN THE DEVELOPMENT OF MECHANICAL AND COLD HYPERSENSITIVITY IN RATS AFTER partial SCIATIC NERVE INJURY

作　　者：徐奭[1] 朱宝长[1] 张耀川[2] 王丹巧[3] 郝景霞 徐晓军 

机构地区：[1]首都师范大学生命科学学院,北京100048 [2]北京农业职业学院园艺系,北京102442 [3]中国中医科学院医学实验中心,北京100700 [4]瑞典卡洛琳斯卡医学院生理药理系,斯德哥尔摩s17177

出　　处：《中国疼痛医学杂志》2013年第3期139-144,共6页Chinese Journal of Pain Medicine

基　　金：科技部国际科技合作项目资助(项目号:2010DFA31890)

摘　　要：目的 :检测大鼠神经部分损伤所致实验性神经病理性痛发生中的性别差异。方法:在成年大鼠中建立部分坐骨神经损伤模型,检测损伤后的机械性痛觉超敏和冷触诱发痛的发展,对比雌雄差异。结果:部分坐骨神经损伤可引起大鼠同侧后足对机械刺激和冷刺激的痛敏反应。虽然雌雄大鼠在机械痛敏程度上没有显著性差异,但雌性大鼠较雄性更早发生痛敏(雌鼠术后1天,雄鼠术后3天)且持续的时程更长(雌鼠术后84天,雄鼠术后49天)。雌性大鼠的冷痛敏比雄性在程度上有显著的增强(P<0.01)。结论:部分坐骨神经损伤引起的大鼠对机械刺激和冷刺激的痛敏现象存在显著的性别差异——雌性大鼠较雄性大鼠表现出更强的神经病理性痛样行为。Objective： To examine the sex differences in the development of experimental neuropathic pain after partial sciatic nerve injury in the rats. Methods： Spared sciatic nerve injury model in adult rats has been established. The injury-induced hypersensitivity to mechanical and cold stimulation （mechanical and cold allodynia） has been studied and sex difference has been examined. Results： Spared sciatic nerve injury produced mechanical and cold hypersensitivity of the ipsilateral hindpaw in rats. Although the magnitude of mechanical hypersensitivity was similar between the two sexes, the hypersensitivity in females occurred earlier （female 1 day, male 3 days） and was more prolonged than males （female 84 days, male 49 days）. The cold hypersensitivity was significantly more severe in females than in male rats （P 〈 0.01）. Conclusion： Rats exhibited neuropathic pain-like behaviors after spared sciatic nerve injury in the forms of mechanical and cold allodynia. There are significant sex differences with female rats developing more severe mechanical and cold hypersensitivity compared with the male rats.

关 键 词：神经病理性痛 性别差异 神经系统 部分坐骨神经损伤模型 

分 类 号：R741[医药卫生—神经病学与精神病学]