The cellular decision between apoptosis and autophagy  

作　　者：Yong-Jun Fan Wei-Xing Zong 

机构地区：[1]Department of Molecular Genetics & Microbiology, Stony Brook University, Stony Brook,NY 11794, USA.

出　　处：《Chinese Journal of Cancer》2013年第3期121-129,共9页

摘　　要：Apoptosis and autophagy are important molecular processes that maintain organismal and cellular homeostasis, respectively. While apoptosis fulfills its role through dismantling damaged or unwanted cells, autophagy maintains cellular homeostasis through recycling selective intracellular organelles and molecules. Yet in some conditions, autophagy can lead to cell death. Apoptosis and autophagy can be stimulated by the same stresses. Emerging evidence indicates an interplay between the core proteins in both pathways, which underlies the molecular mechanism of the crosstalk between apoptosis and autophagy. This review summarizes recent literature on molecules that regulate both the apoptotic and autophagic processes.Apoptosis and autophagy are important molecular processes that maintain organismal and cellular homeostasis, respectively. While apoptosis fulfills its role through dismantling damaged or unwanted cells, autophagy maintains cellular homeostasis through recycling selective intracellular organelles and molecules. Yet in some conditions, autophagy can lead to cell death. Apoptosis and autophagy can be stimulated by the same stresses. Emerging evidence indicates an interplay between the core proteins in both pathways, which underlies the molecular mechanism of the crosstalk between apoptosis and autophagy. This review summarizes recent literature on molecules that regulate both the apoptotic and autophagic processes.

关 键 词：细胞凋亡 自噬作用 分子过程 细胞死亡 相互作用 核心蛋白 分子机制 有机体 

分 类 号：R73-3[医药卫生—肿瘤]