Ultrasound-mediated targeted microbubbles： a new vehicle for cancer therapy  

作　　者：Junxiao YE Huining HE Junbo GONG Weibing DONG Yongzhuo HUANG Jianxin WANG Guanyi CHEN Victor C YANG 

机构地区：[1]School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China [2]Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China [3]Department of Pharmaceutics, School of Pharmacy, Fudan University Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, Shanghai 201203, China [4]School of Environmental Science and Engineering, State Key Laboratory of Engines, Tianjin University, Tianjin 300072, China [5]Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China [6]Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USA

出　　处：《Frontiers of Chemical Science and Engineering》2013年第1期20-28,共9页化学科学与工程前沿（英文版）

摘　　要：With the hope of overcoming the serious side effects, great endeavor has been made in tumor-targeted chemotherapy, and various drug delivery modalities and drug carriers have been made to decrease systemic toxicity caused by chemotherapeutic agents. Scientists from home and abroad focus on the research of targeted microbubbles contrast agent, and the use of the targeted ultrasound microbubble contrast agent can carry gene drugs and so on to the target tissue, as well as mediated tumor cell apoptosis and tumor microvascular thrombosis block, etc., thus plays the role of targeted therapy. Recent studies have elucidated the mechanisms of drug release and absorption, however, much work remains to be done in order to develop a successful and optimal system. In this review, we summarized the continuing efforts in under-standing the usage of the ultrasound triggered target microbubbles in cancer therapy, from release mechanism to preparation methods. The latest applications of ultra-sound-triggered targeted microbubbles in cancer therapy, especially in gene therapy and antiangiogenic cancer therapy were discussed. Moreover, we concluded that as a new technology, ultrasound-triggered targeted microbubbles used as drug carriers and imaging agents are still energetic and are very likely to be translated into clinic in the near future.With the hope of overcoming the serious side effects, great endeavor has been made in tumor-targeted chemotherapy, and various drug delivery modalities and drug carriers have been made to decrease systemic toxicity caused by chemotherapeutic agents. Scientists from home and abroad focus on the research of targeted microbubbles contrast agent, and the use of the targeted ultrasound microbubble contrast agent can carry gene drugs and so on to the target tissue, as well as mediated tumor cell apoptosis and tumor microvascular thrombosis block, etc., thus plays the role of targeted therapy. Recent studies have elucidated the mechanisms of drug release and absorption, however, much work remains to be done in order to develop a successful and optimal system. In this review, we summarized the continuing efforts in under-standing the usage of the ultrasound triggered target microbubbles in cancer therapy, from release mechanism to preparation methods. The latest applications of ultra-sound-triggered targeted microbubbles in cancer therapy, especially in gene therapy and antiangiogenic cancer therapy were discussed. Moreover, we concluded that as a new technology, ultrasound-triggered targeted microbubbles used as drug carriers and imaging agents are still energetic and are very likely to be translated into clinic in the near future.

关 键 词：ultrasound-mediated targeted microbubbles CANCER 

分 类 号：TQ174.759[化学工程—陶瓷工业] TD456[化学工程—硅酸盐工业]